Department of Clinical Neurobiology of the Medical Faculty of Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Science. 2012 Mar 23;335(6075):1506-10. doi: 10.1126/science.1217139.
The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.
海马体和内嗅皮层在空间学习和记忆中发挥着关键作用。这两个前脑区域通过兴奋性通路高度相互连接。使用光遗传学工具，我们鉴定并描述了长程 γ-氨基丁酸释放（GABAergic）神经元，它们提供了双向的海马-内嗅抑制性连接，并优先靶向 GABAergic 中间神经元。长程 GABAergic 轴突的激活增强了靶区中突触后神经元的亚阈值和超阈值节律性θ活动。
