Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.
Immunol Res. 2012 Dec;54(1-3):254-61. doi: 10.1007/s12026-012-8303-9.
Adaptations in maternal systemic immunity are presumed to be responsible for observed alterations in disease susceptibility and severity as pregnancy progresses. Epidemiological evidence as well as animal studies have shown that influenza infections are more severe during the second and third trimesters of pregnancy, resulting in greater morbidity and mortality, although the reason for this is still unclear. Our laboratory has taken advantage of 20 years of experience studying the murine immune response to respiratory viruses to address questions of altered immunity during pregnancy. With clinical studies and unique animal model systems, we are working to define the mechanisms responsible for altered immune responses to influenza infection during pregnancy and what roles hormones such as estrogen or progesterone play in these alterations.
母体系统免疫的适应性被认为是导致妊娠期间疾病易感性和严重程度变化的原因。流行病学证据和动物研究表明，流感感染在妊娠的第二和第三个三个月更为严重，导致更高的发病率和死亡率，尽管其原因尚不清楚。我们的实验室利用 20 年来研究小鼠对呼吸道病毒的免疫反应的经验，来解决妊娠期间免疫改变的问题。通过临床研究和独特的动物模型系统，我们正在努力确定导致妊娠期间流感感染免疫反应改变的机制，以及雌激素或孕激素等激素在这些改变中所起的作用。
