Cogn Neuropsychol. 1998 Sep 1;15(6-8):645-83. doi: 10.1080/026432998381041.
We report an experimental study of the factors that elicit manual interference in a patient with so-called "anarchic hand" behaviour in everyday life (Della Sala, Marchetti, & Spinnler, 1991, 1994) due to corticobasilar degeneration. The patient, ES, showed problems with both hands. We used tests in which ES had to respond to a left-side object with her left hand and to a right-side object with her right hand; manual interference responses occurred when she used the left hand to respond to the right-side object and the right hand to respond to left-side objects. In reaching tasks, interference responses were determined by stimulus familiarity and by the spatial relations between the hand of response and the part of the object used for action (the handle of the cup). In pointing tasks interference responses were affected by both effector and spatial uncertainty. Right hand responses were affected particularly by familiarity, and left hand responses by effector and spatial uncertainty. The results demonstrate that visual affordances (determined by object-hand compatibility) and visual familiarity can directly activate motor responses. Hand differences are discussed in terms of hemispheric specialisation for different components of motor action.
我们报告了一项实验研究，该研究旨在探讨在日常生活中因皮质基底节变性而出现所谓“混乱手”行为的患者（Della Sala、 Marchetti 和 Spinnler，1991 年，1994 年）中，哪些因素会引起手部的干扰。患者 ES 双手均有问题。我们使用了一些测试，要求 ES 用左手对左侧物体做出反应，用右手对右侧物体做出反应；当她用左手对右侧物体做出反应，用右手对左侧物体做出反应时，就会出现手部干扰反应。在伸手任务中，干扰反应取决于刺激的熟悉程度以及手与用于操作的物体部分（杯子的把手）之间的空间关系。在指向任务中，干扰反应受到效应器和空间不确定性的影响。右手反应受熟悉度影响较大，左手反应受效应器和空间不确定性影响较大。结果表明，视觉可供性（由物体与手的兼容性决定）和视觉熟悉度可以直接激活运动反应。根据运动动作的不同成分的半球专业化，对手部差异进行了讨论。
