来源于浙贝母的甾体皂苷。
Steroidal saponins from Fritillaria pallidiflora Schrenk.
机构信息
School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China.
出版信息
Fitoterapia. 2012 Jun;83(4):785-94. doi: 10.1016/j.fitote.2012.03.008. Epub 2012 Mar 16.
Five new steroidal saponins, Pallidifloside D (1), Pallidifloside E (2), Pallidifloside G (5), Pallidifloside H (6) and Pallidifloside I (7), together with seven other steroidal saponins (3, 4, 8-12) were isolated from the dry bulbs of Fritillaria pallidiflora Schrenk. Their structures were established by spectroscopic techniques (IR, MS, 1D and 2D NMR) and chemical means. The isolated steroidal saponins were evaluated for cyotoxic activity against human C6 brain gliomas and Hela cervix cancer cell lines using MTT assays. Compounds 1, 10, 11, 12 showed cytotoxicity against C6 and Hela cell lines with IC(50) values in the range of 5.1-75.8μM.
从百合科植物伊犁贝母(Fritillaria pallidiflora Schrenk)的干燥鳞茎中分离得到了 5 个新甾体皂苷化合物，分别命名为 Pallidifloside D（1）、Pallidifloside E（2）、Pallidifloside G（5）、Pallidifloside H（6）和 Pallidifloside I（7），以及另外 7 个甾体皂苷化合物（3、4、8-12）。通过光谱技术（IR、MS、1D 和 2D NMR）和化学方法确定了它们的结构。采用 MTT 法评价了分离得到的甾体皂苷对人 C6 脑胶质瘤和 Hela 宫颈癌细胞系的细胞毒性。化合物 1、10、11、12 对 C6 和 Hela 细胞系具有细胞毒性，IC50 值在 5.1-75.8μM 范围内。
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