短梗菝葜根茎和根中的四种新呋甾烷醇皂苷及其细胞毒性。

Four new furostanol saponins from the rhizomes and roots of Smilax scobinicaulis and their cytotoxicity.

作者信息

Xu Jing, Feng Shixiu, Wang Qi, Cao Yingli, Sun Miao, Zhang Cunli

机构信息

College of Life Science, Northwest A&F University, Yangling 712100, Shaanxi, China.

Key Laboratory of Southern Subtropical Plant Diversity, Shenzhen Fairy Lake Botanical Garden, Chinese Academy of Sciences, 160 Xianhu Road, Liantang, Shenzhen 518004, China.

出版信息

Molecules. 2014 Dec 15;19(12):20975-87. doi: 10.3390/molecules191220975.

DOI:10.3390/molecules191220975

PMID:25517339

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6271347/

Abstract

Four new furostanol saponins 1-4, along with two known furostanol saponins 5 and 6 and one known spirostanol saponin 7 were isolated from the rhizomes and roots of Smilax scobinicaulis. The structures of the new saponins were elucidated as 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one-3-O-α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside (1), 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one (2), 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-20(22)-en-6-one (3), 26-O-β-D-glucopyranoside-3β,23,26-trihydroxy-(23R, 25R)-5α-furostan-20(22)-en-6-one (4) on the basis of spectroscopic analysis. The isolated saponins were evaluated for cytotoxic activity against two human cancer cell lines including Hela (cervical carcinoma) and SMMC-7221 (hepatocellular carcinoma). Compounds 1 and 7 demonstrated cytotoxicity against the tested cell lines.

摘要

从菝葜的根茎中分离得到4个新的呋甾烷醇皂苷1-4，以及2个已知的呋甾烷醇皂苷5和6和1个已知的螺旋甾烷醇皂苷7。通过光谱分析确定新皂苷的结构分别为26-O-β-D-吡喃葡萄糖苷-3β,26-二羟基-(25R)-5α-呋甾烷-22-甲氧基-6-酮-3-O-α-L-吡喃阿拉伯糖苷-(1→6)-β-D-吡喃葡萄糖苷(1)、26-O-β-D-吡喃葡萄糖苷-3β,26-二羟基-(25R)-5α-呋甾烷-22-甲氧基-6-酮(2)、26-O-β-D-吡喃葡萄糖苷-3β,26-二羟基-(25R)-5α-呋甾烷-20(22)-烯-6-酮(3)、26-O-β-D-吡喃葡萄糖苷-3β,23,26-三羟基-(23R,25R)-5α-呋甾烷-20(22)-烯-6-酮(4)。对分离得到的皂苷进行了针对两种人类癌细胞系（包括Hela（宫颈癌）和SMMC-7221（肝癌））的细胞毒性活性评估。化合物1和7对测试的细胞系表现出细胞毒性。