Saraji Mohammad, Khaje Nasrin
Department of Chemistry, Isfahan University of Technology, Isfahan, Iran.
Bioanalysis. 2012 Mar;4(6):725-39. doi: 10.4155/bio.12.26.
Sample preparation is an important and necessary step in a measurement process for isolation and concentration of desired components from complex matrices. It is the most time-consuming and error-prone step in analytical methodology, greatly affecting quality and quantity of analytical data. During the past 15 years, solvent microextraction techniques have been introduced as alternatives to conventional sample preparation methods, such as liquid-liquid extraction and solid-phase extraction. These novel methodologies, which have proved to be extremely simple, low-cost and virtually solvent-free sample-preparation techniques provide a high degree of selectivity, sample cleanup and enrichment. The aim of the present review is to explore recent analytical applications of solvent microextraction techniques for quantification of drugs in biological samples, with particular focus on the methods involving MS as a detection system.
样品制备是测量过程中的一个重要且必要的步骤，用于从复杂基质中分离和浓缩所需成分。它是分析方法中最耗时且最容易出错的步骤，极大地影响分析数据的质量和数量。在过去的15年里，溶剂微萃取技术作为传统样品制备方法（如液 - 液萃取和固相萃取）的替代方法被引入。这些新颖的方法已被证明是极其简单、低成本且几乎无溶剂的样品制备技术，具有高度的选择性、样品净化和富集能力。本综述的目的是探讨溶剂微萃取技术在生物样品中药物定量分析的最新应用，特别关注涉及质谱作为检测系统的方法。
