Hospital Universitario Puerta de Hierro Majadahonda, Department of Psychiatry, Madrid, Spain.
Acta Paediatr. 2012 Jul;101(7):749-54. doi: 10.1111/j.1651-2227.2012.02668.x. Epub 2012 Apr 4.
To investigate the effect intrapartum oxytocin administration can have on Primitive Neonatal Reflexes. The secondary objective was to observe the influence of intrapartum oxytocin may have on breastfeeding.
Twenty healthy primiparae with a single gestation at term were included. To assess Primitive Neonatal Reflexes, video film was taken during an experimental situation designed to elicit Primitive Neonatal Reflexes. Three independent observers blinded to the oxytocin dose that had been administered coded the Primitive Neonatal Reflexes. Data regarding breastfeeding were collected by telephone at 3 months.
Medium oxytocin dose was 1931.9 ± 1754.4 mUI. A Kappa index >0.75 was obtained for four Primitive Neonatal Reflexes: swallow, jaw jerk, suck and gazing. A negative association was found between oxytocin dose and sucking (p = 0.03). At 3 months of life, women exclusively breastfeeding (63.1%) had received a significantly lower average dose of oxytocin than those not exclusively breastfeeding (36.8%) (p = 0.04).
In this pilot study, intrapartum exogenous oxytocin seems to disturb sucking and breastfeeding duration. Further studies are required to confirm these results and to ascertain whether there could be other effects of intrapartum oxytocin on newborn behaviour.
研究分娩时给予催产素对原始新生儿反射的影响。次要目的是观察分娩时给予催产素对母乳喂养的影响。
纳入 20 名健康的初产妇，单胎足月妊娠。为了评估原始新生儿反射，在设计用于引出原始新生儿反射的实验情况下拍摄视频。三名独立的观察者对给予的催产素剂量不知情，对原始新生儿反射进行编码。通过电话在 3 个月时收集母乳喂养的数据。
中等催产素剂量为 1931.9±1754.4 mUI。有四种原始新生儿反射的 Kappa 指数>0.75：吞咽、下颌反射、吸吮和凝视。催产素剂量与吸吮之间存在负相关（p=0.03）。在 3 个月大时，纯母乳喂养（63.1%）的女性接受的催产素平均剂量明显低于非纯母乳喂养（36.8%）的女性（p=0.04）。
在这项初步研究中，分娩时外源性催产素似乎会干扰吸吮和母乳喂养的持续时间。需要进一步的研究来证实这些结果，并确定分娩时催产素是否对新生儿行为有其他影响。
