Omaru Machiko, Kajiwara Setsu, Wakamatsu Eri, Kuroishi Sumiko, Ochiai Yukifumi, Oniki Kentaro, Kato Kiyoko, Morokuma Seiichi
Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Department of Nursing, Comprehensive Maternity and Perinatal Care Center, Kyushu University Hospital, Fukuoka, 812-8582, Japan.
Sci Rep. 2024 Mar 11;14(1):5859. doi: 10.1038/s41598-024-56635-9.
This study aimed to examine the effect of intrapartum oxytocin administration on neonatal sucking behavior and breastfeeding. A total of 64 pairs (29 in the group treated with intrapartum oxytocin and 35 in the control group) of normal infants within 24-48 h of birth and their mothers were recruited. Sucking ability was evaluated by measuring Non-Nutritive Sucking (NNS) for 5 min. Data on the rate of exclusive breastfeeding at 1 month postpartum were collected. In the adjusted multiple regression models, intrapartum oxytocin exposure was significantly associated with fewer total NNS bursts (95% confidence interval (CI), -7.02 to -0.22), longer pause times (95% CI, 1.33 to 10.21), and greater pause-time variability (95% CI, 3.63 to 63.92). Effects estimated using structural equation modeling revealed that intrapartum oxytocin exposure had a significant negative and direct effect on the practice of exclusive breastfeeding 1 month postpartum (β = -0.238, p = 0.047). However, no NNS-mediated indirect effects were observed. This report demonstrates that infants born to mothers who receive intrapartum oxytocin may have impaired sucking ability for at least the first 48 h after birth, and breastfeeding support should be provided.
本研究旨在探讨产时使用缩宫素对新生儿吸吮行为及母乳喂养的影响。共招募了64对母婴，其中29对母婴的母亲在产时使用了缩宫素，35对母婴作为对照组。这些婴儿均为正常新生儿，出生后24至48小时内入组，同时纳入他们的母亲。通过测量5分钟的非营养性吸吮（NNS）来评估吸吮能力。收集产后1个月时纯母乳喂养率的数据。在调整后的多元回归模型中，产时暴露于缩宫素与总NNS爆发次数减少（95%置信区间（CI），-7.02至-0.22）、停顿时间延长（95%CI，1.33至10.21）以及停顿时间变异性增加（95%CI，3.63至63.92）显著相关。使用结构方程模型估计的结果显示，产时暴露于缩宫素对产后1个月纯母乳喂养行为有显著的负向直接影响（β = -0.238，p = 0.047）。然而，未观察到NNS介导的间接影响。本报告表明，母亲在产时接受缩宫素的婴儿在出生后的至少头48小时内吸吮能力可能受损，应提供母乳喂养支持。
