Division of Endocrinology, Metabolism & Genetics, The University of Kansas Medical Center, 3901 Rainbow Blvd, Mailstop 2024, Kansas City, KS 66160, USA.
Nutr Metab (Lond). 2012 Mar 27;9:24. doi: 10.1186/1743-7075-9-24.
Calcium is one of the most abundant minerals in the body and its metabolism is one of the basic biologic processes in humans. Although historically linked primarily to bone structural development and maintenance, calcium is now recognized as a key component of many physiologic pathways necessary for optimum health including cardiovascular, neurological, endocrine, renal, and gastrointestinal systems. A recent meta-analysis published in August 2011 showed a potential increase in cardiovascular events related to calcium supplementation. The possible mechanism of action of this correlation has not been well elucidated. This topic has generated intense interest due to the widespread use of calcium supplements, particularly among the middle aged and elderly who are at the most risk from cardiac events. Prior studies did not control for potential confounding factors such as the use of statins, aspirin or other medications. These controversial results warrant additional well-designed studies to investigate the relationship between calcium supplementation and cardiovascular outcomes. The purpose of this review is to highlight the current literature in regards to calcium supplementation and cardiovascular health; and to identify areas of future research.
钙是人体中含量最丰富的矿物质之一，其代谢是人体的基本生物学过程之一。尽管钙在历史上主要与骨骼结构的发育和维持有关，但现在已被认为是许多生理途径的关键组成部分，这些途径对最佳健康至关重要，包括心血管、神经、内分泌、肾脏和胃肠道系统。2011 年 8 月发表的一项最新荟萃分析显示，钙补充剂与心血管事件的发生有关。这种相关性的可能作用机制尚未得到很好的阐明。由于钙补充剂的广泛使用，特别是在从中年到老年的人群中，这些人群最容易发生心脏事件，因此这个话题引起了极大的兴趣。先前的研究没有控制他汀类药物、阿司匹林或其他药物等潜在混杂因素。这些有争议的结果需要进一步精心设计的研究来调查钙补充剂与心血管结局之间的关系。本文的目的是强调目前关于钙补充剂与心血管健康的文献，并确定未来研究的领域。
