Grepstad Jon Olav, Kaspar Peter, Solgaard Olav, Johansen Ib-Rune, Sudbø Aasmund S
Department of Electronics and Telecommunications, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.
Opt Express. 2012 Mar 26;20(7):7954-65. doi: 10.1364/OE.20.007954.
A sensor designed to detect bio-molecules is presented. The sensor exploits a planar 2D photonic crystal (PC) membrane with sub-micron thickness and through holes, to induce high optical fields that allow detection of nano-particles smaller than the diffraction limit of an optical microscope. We report on our design and fabrication of a PC membrane with a nano-particle trapped inside. We have also designed and built an imaging system where an optical microscope and a CCD camera are used to take images of the PC membrane. Results show how the trapped nano-particle appears as a bright spot in the image. In a first experimental realization of the imaging system, single particles with a radius of 75 nm can be detected.
本文介绍了一种用于检测生物分子的传感器。该传感器利用具有亚微米厚度和通孔的平面二维光子晶体(PC)膜,以诱导产生高光学场,从而能够检测小于光学显微镜衍射极限的纳米颗粒。我们报告了我们对内部捕获有纳米颗粒的PC膜的设计与制造。我们还设计并构建了一个成像系统,其中使用光学显微镜和电荷耦合器件(CCD)相机对PC膜进行成像。结果表明,捕获的纳米颗粒在图像中呈现为一个亮点。在成像系统的首次实验实现中,能够检测到半径为75纳米的单个颗粒。