Physical Medicine and Rehabilitation Department, Göztepe Training and Research Hospital, Medeniyet University, Istanbul, Turkey.
Rheumatol Int. 2013 Feb;33(2):423-7. doi: 10.1007/s00296-012-2399-z. Epub 2012 Mar 28.
There has been a recent interest in calcitonin as a potential treatment for osteoarthritis, based on its metabolic activities in both bone turnover and cartilage. The aim of this study was to evaluate the effects of nasal form calcitonin on knee osteoarthritis and quality of life in women who receive calcitonin treatment for postmenopausal osteoporosis. Two hundred and twenty postmenopausal women, aged between 55 and 65 years with knee pain and knee osteoarthritis, graded II-III by using Kellgren-Lawrence radiographic scoring system, were included. Western Ontario and McMaster Universities (WOMAC) osteoarthritis index, the quality of life questionnaire of the European Foundation for Osteoporosis (QALEFFO-41) and visual analog scale were used for the algofunctional assessments. Need of rescue analgesic was recorded. Pain (P < 0.001), stiffness (P < 0.05), functional capability (P < 0.05) and total score of WOMAC (P < 0.05) revealed statistically significant improvements after 3 months of the treatment and remained consistent throughout 1 year of the treatment period. Participants experienced significant reductions in WOMAC perceptions of pain (-53 %), joint stiffness (-44 %) and limitations in physical function (-49 %) at the end of 1 year of calcitonin treatment. Need of rescue analgesic intake was reported to have decreased approximately by 60 % at the end of the 1-year treatment period. QUALEFFO_41 scores improved: 37.6 (baseline), 30.9 (3 months), 28.0 (6 months) and 24.4 (1 year). In conclusion, nasal calcitonin treatment provided dual action on osteoporosis and osteoarthritis with significant improvements in quality of life and algofunctional results in knee osteoarthritis.
最近，人们对降钙素作为治疗骨关节炎的潜在药物产生了兴趣，这是基于其在骨转换和软骨代谢中的活性。本研究旨在评估鼻用降钙素对接受降钙素治疗绝经后骨质疏松症的女性膝关节骨关节炎和生活质量的影响。纳入了 220 名年龄在 55 至 65 岁之间、有膝关节疼痛和膝关节骨关节炎的绝经后女性，其膝关节骨关节炎的 Kellgren-Lawrence 放射评分系统分级为 II-III 级。采用 Western Ontario 和 McMaster 大学（WOMAC）骨关节炎指数、欧洲骨质疏松症基金会生活质量问卷（QALEFFO-41）和视觉模拟评分法进行algofunctional 评估。记录了需要急救镇痛的情况。治疗 3 个月后，WOMAC 的疼痛（P<0.001）、僵硬（P<0.05）、功能能力（P<0.05）和总分（P<0.05）均有统计学显著改善，且在治疗期间的 1 年内保持一致。接受降钙素治疗 1 年后，WOMAC 对疼痛（-53%）、关节僵硬（-44%）和身体功能受限（-49%）的感知有显著改善。治疗 1 年后，需要急救镇痛的摄入量报告减少了约 60%。QUALEFFO_41 评分提高：37.6（基线）、30.9（3 个月）、28.0（6 个月）和 24.4（1 年）。总之，鼻用降钙素治疗对骨质疏松症和骨关节炎有双重作用，可显著改善膝关节骨关节炎的生活质量和 algofunctional 结果。
