Karsdal M A, Tanko L B, Riis B J, Sondergard B C, Henriksen K, Altman R D, Qvist P, Christiansen C
Nordic Bioscience Diagnostics, Herlev, Denmark.
Osteoarthritis Cartilage. 2006 Jul;14(7):617-24. doi: 10.1016/j.joca.2006.03.014. Epub 2006 May 12.
Osteoarthritis (OA) is the most common form of degenerative joint diseases and a major cause of disability and impaired quality of life in the elderly. Recent observations suggest that calcitonin may act on both osteoclasts and chondrocytes. The present review was sought to summarize emerging observations from the molecular level to the preliminary clinical findings of possible chondroprotective effects of calcitonin.
This review summarizes peer-reviewed articles found using pre-defined search criteria and published in the PubMed database before January 2006. In addition, abstracts from the OsteoArthritis Research Society International (OARSI) conferences in the time period 2000-2005 have been included in the search.
Ample evidence for the effect of calcitonin on bone resorption was found. Support for direct effects of calcitonin on chondrocytes on matrix synthesis and inhibition of cartilage degradation have been published. In addition, clinical evidence for the effect of calcitonin on cartilage degradation is emerging.
Several independent lines of evidence suggest a direct chondroprotective effect of calcitonin in addition to the well-established effect on bone resorption. Given the currently limited availability of chondroprotective agents, much expectation regards the ongoing clinical assessment of calcitonin therapy for the prevention and treatment of OA.
骨关节炎（OA）是最常见的退行性关节疾病形式，也是老年人残疾和生活质量受损的主要原因。最近的观察表明，降钙素可能作用于破骨细胞和软骨细胞。本综述旨在总结从分子水平到降钙素可能具有软骨保护作用的初步临床研究结果等新出现的观察结果。
本综述总结了使用预定义搜索标准找到并于2006年1月之前发表在PubMed数据库中的同行评审文章。此外，2000 - 2005年期间国际骨关节炎研究学会（OARSI）会议的摘要也被纳入搜索范围。
发现了大量关于降钙素对骨吸收作用的证据。关于降钙素对软骨细胞基质合成的直接作用以及对软骨降解的抑制作用的支持性研究已经发表。此外，降钙素对软骨降解作用的临床证据也正在出现。
几条独立的证据表明，除了对骨吸收的既定作用外，降钙素还具有直接的软骨保护作用。鉴于目前软骨保护剂的可用性有限，人们对降钙素治疗骨关节炎的预防和治疗的正在进行的临床评估寄予厚望。
