State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Rd. 38, Beijing 100191, China.
Chem Commun (Camb). 2012 May 11;48(37):4498-500. doi: 10.1039/c2cc30684k. Epub 2012 Mar 28.
An efficient TEMPO-catalyzed oxidative C-C bond formation with two Csp(3)-H bonds using molecular oxygen as the oxidant has been developed. The novel transformation provides a new strategy for the TEMPO-O(2) catalysis to construct C-C bonds. The advantages of this method include: (1) relatively mild and neutral conditions; (2) simplicity and safety of operation; (3) a stoichiometric amount of dangerous oxidants, any transition metals, additives, even solvent, is not required.
发展了一种高效的 TEMPO 催化氧化 C-C 键形成反应，该反应利用分子氧作为氧化剂，涉及两个 Csp(3)-H 键。这种新颖的转化为 TEMPO-O(2)催化构建 C-C 键提供了一种新策略。该方法的优点包括：（1）条件相对温和且呈中性；（2）操作简单且安全；（3）不需要使用化学计量的危险氧化剂、任何过渡金属、添加剂，甚至溶剂。
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