蛋白激酶 C 的生物学

The biology of protein kinase C.

机构信息

School of Medicine, University of California, San Francisco, CA, USA.

出版信息

Adv Exp Med Biol. 2012;740:639-61. doi: 10.1007/978-94-007-2888-2_28.

Abstract

This review gives a basic introduction to the biology of protein kinase C, one of the first calcium-dependent kinases to be discovered. We review the structure and function of protein kinase C, along with some of the substrates of individual isoforms. We then review strategies for inhibiting PKC in experimental systems and finally discuss the therapeutic potential of targeting PKC. Each aspect is covered in summary, with links to detailed resources where appropriate.

摘要

这篇综述简要介绍了蛋白激酶 C 的生物学特性，蛋白激酶 C 是最早被发现的钙依赖性激酶之一。我们综述了蛋白激酶 C 的结构和功能，以及各个同工型的部分底物。接着，我们综述了在实验系统中抑制蛋白激酶 C 的策略，最后讨论了针对蛋白激酶 C 的治疗潜力。在适当的情况下，每个方面都附有链接，以指向详细的资源。