基于 18F-FDG PET 的纹理特征分析评估肿瘤摄取异质性的可重复性。
Reproducibility of tumor uptake heterogeneity characterization through textural feature analysis in 18F-FDG PET.
机构信息
LaTIM, INSERM UMR1101, CHRU Morvan, Brest, France.
出版信息
J Nucl Med. 2012 May;53(5):693-700. doi: 10.2967/jnumed.111.099127. Epub 2012 Mar 27.
UNLABELLED
(18)F-FDG PET measurement of standardized uptake value (SUV) is increasingly used for monitoring therapy response and predicting outcome. Alternative parameters computed through textural analysis were recently proposed to quantify the heterogeneity of tracer uptake by tumors as a significant predictor of response. The primary objective of this study was to evaluate the reproducibility of these heterogeneity measurements.
METHODS
Double baseline (18)F-FDG PET scans were acquired within 4 d of each other for 16 patients before any treatment was considered. A Bland-Altman analysis was performed on 8 parameters based on histogram measurements and 17 parameters based on textural heterogeneity features after discretization with values between 8 and 128.
RESULTS
The reproducibility of maximum and mean SUV was similar to that in previously reported studies, with a mean percentage difference of 4.7% ± 19.5% and 5.5% ± 21.2%, respectively. By comparison, better reproducibility was measured for some textural features describing local heterogeneity of tracer uptake, such as entropy and homogeneity, with a mean percentage difference of -2% ± 5.4% and 1.8% ± 11.5%, respectively. Several regional heterogeneity parameters such as variability in the intensity and size of regions of homogeneous activity distribution had reproducibility similar to that of SUV measurements, with 95% confidence intervals of -22.5% to 3.1% and -1.1% to 23.5%, respectively. These parameters were largely insensitive to the discretization range.
CONCLUSION
Several parameters derived from textural analysis describing heterogeneity of tracer uptake by tumors on local and regional scales had reproducibility similar to or better than that of simple SUV measurements. These reproducibility results suggest that these (18)F-FDG PET-derived parameters, which have already been shown to have predictive and prognostic value in certain cancer models, may be used to monitor therapy response and predict patient outcome.
目的
（18）F-FDG PET 摄取标准摄取值（SUV）的测量值越来越多地用于监测治疗反应和预测预后。最近提出了通过纹理分析计算的替代参数，以量化肿瘤摄取示踪剂的异质性，这是反应的一个重要预测指标。本研究的主要目的是评估这些异质性测量的可重复性。
方法
16 例患者在考虑任何治疗之前的 4 天内分别进行了两次基线（18）F-FDG PET 扫描。对 8 个基于直方图测量的参数和 17 个基于纹理异质性特征的参数进行了 Bland-Altman 分析，这些参数经过离散化后取值范围在 8 到 128 之间。
结果
最大和平均 SUV 的可重复性与以前报道的研究相似，平均百分比差异分别为 4.7%±19.5%和 5.5%±21.2%。相比之下，一些描述示踪剂摄取局部异质性的纹理特征具有更好的可重复性，例如熵和同质性，平均百分比差异分别为-2%±5.4%和 1.8%±11.5%。一些区域性异质性参数，如同质活性分布区域强度和大小的变异性，其可重复性与 SUV 测量值相似，95%置信区间分别为-22.5%至 3.1%和-1.1%至 23.5%。这些参数对离散化范围不敏感。
结论
一些描述肿瘤摄取示踪剂局部和区域异质性的纹理分析衍生参数的可重复性与简单 SUV 测量值相似或更好。这些可重复性结果表明，这些（18）F-FDG PET 衍生参数已经在某些癌症模型中显示出具有预测和预后价值，可能用于监测治疗反应和预测患者预后。
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