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曼陀罗树提取物及其次生代谢物对小鼠吗啡耐受和依赖的影响。

Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice.

机构信息

Pharmacognosy Unit, School of Pharmacy, University of Camerino, Via Madonna delle Carceri 9, 62032 Camerino, Italy.

出版信息

Evid Based Complement Alternat Med. 2012;2012:741925. doi: 10.1155/2012/741925. Epub 2012 Feb 8.

DOI:10.1155/2012/741925
PMID:22454681
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3290905/
Abstract

The aim of the present study was to investigate, in vivo, the effect of a Brugmansia arborea extract (BRU), chromatographic fractions (FA and FNA), and isolated alkaloids on the expression and the acquisition of morphine tolerance and dependence. Substances were acutely (for expression) or repeatedly (for acquisition) administered in mice treated with morphine twice daily for 5 or 6 days, in order to make them tolerant or dependent. Morphine tolerance was assessed using the tail-flick test at 1st and 5th days. Morphine dependence was evaluated through the manifestation of withdrawal symptoms induced by naloxone injection at 6th day. Results showed that BRU significantly reduced the expression of morphine tolerance, while it was ineffective to modulate its acquisition. Chromatographic fractions and pure alkaloids failed to reduce morphine tolerance. Conversely BRU, FA, and pure alkaloids administrations significantly attenuated both development and expression of morphine dependence. These data suggest that Brugmansia arborea Lagerh might have human therapeutic potential for treatment of opioid addiction.

摘要

本研究旨在体内研究布鲁氏菌 arborea 提取物（BRU）、色谱馏分（FA 和 FNA）和分离生物碱对吗啡耐受和依赖表达和获得的影响。将这些物质急性（用于表达）或反复（用于获得）给予每天两次接受吗啡处理 5 或 6 天的小鼠，以使其耐受或依赖。在第 1 天和第 5 天，使用尾巴敲击试验评估吗啡耐受。通过在第 6 天注射纳洛酮诱导戒断症状来评估吗啡依赖。结果表明，BRU 显著降低了吗啡耐受的表达，而对其获得没有调节作用。色谱馏分和纯生物碱未能降低吗啡耐受。相反，BRU、FA 和纯生物碱的给药显著减弱了吗啡依赖的发展和表达。这些数据表明，布鲁氏菌 arborea Lagerh 可能具有治疗阿片类药物成瘾的人类治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/60f2e0a1f2d7/ECAM2012-741925.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/b684ce117949/ECAM2012-741925.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/0f061a4bcaa7/ECAM2012-741925.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/3f11c4a1d630/ECAM2012-741925.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/5441ed70aad9/ECAM2012-741925.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/bc433fedce56/ECAM2012-741925.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/60f2e0a1f2d7/ECAM2012-741925.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/b684ce117949/ECAM2012-741925.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/0f061a4bcaa7/ECAM2012-741925.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/3f11c4a1d630/ECAM2012-741925.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/5441ed70aad9/ECAM2012-741925.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/bc433fedce56/ECAM2012-741925.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3991/3290905/60f2e0a1f2d7/ECAM2012-741925.006.jpg

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3
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