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局部应用拉坦前列素后发生免疫性角膜移植排斥反应：2例报告

Immunologic corneal graft rejection after administration of topical latanoprost: a report of two patients.

作者信息

Nouri-Mahdavi Kouros, Javadi Mohammad-Ali, Jafarinasab Mohammad-Reza

机构信息

Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA.

出版信息

J Ophthalmic Vis Res. 2011 Apr;6(2):127-30.

PMID:22454722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3306091/
Abstract

PURPOSE

To report endothelial corneal graft rejection after administration of topical latanoprost eye drops.

CASE REPORT

Two eyes of two patients with a history of multiple intraocular procedures prior to penetrating keratoplasty developed endothelial graft rejection one month after administration of topical latanoprost. Cystoid macular edema developed simultaneously in one patient.

CONCLUSION

Latanoprost may trigger endothelial graft rejection in susceptible eyes.

摘要

目的

报告局部应用拉坦前列素滴眼液后发生的角膜内皮移植排斥反应。

病例报告

两名患者在穿透性角膜移植术前有多次眼内手术史，在局部应用拉坦前列素一个月后，两只眼均发生了内皮移植排斥反应。其中一名患者同时出现了黄斑囊样水肿。

结论

拉坦前列素可能会引发易感眼的内皮移植排斥反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5ab/3306091/3417990d4ce8/jovr-6-2-127f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5ab/3306091/3417990d4ce8/jovr-6-2-127f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5ab/3306091/3417990d4ce8/jovr-6-2-127f1.jpg

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Surv Ophthalmol. 2008 Nov;53 Suppl1:S93-105. doi: 10.1016/j.survophthal.2008.08.004.
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拉坦前列素与高危无晶状体或人工晶状体眼的黄斑囊样水肿
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Latanoprost and cystoid macular edema: is there a causal relation?
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Latanoprost as a new horizon in the medical management of glaucoma.拉坦前列素——青光眼药物治疗的新进展
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Latanoprost accelerates disruption of the blood-aqueous barrier and the incidence of angiographic cystoid macular edema in early postoperative pseudophakias.拉坦前列素会加速人工晶状体植入术后早期血-房水屏障的破坏以及血管造影性黄斑囊样水肿的发生率。
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Cystoid macular edema associated with latanoprost in aphakic and pseudophakic eyes.无晶状体眼和人工晶状体眼中与拉坦前列素相关的黄斑囊样水肿。
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Anterior uveitis associated with latanoprost.与拉坦前列素相关的前葡萄膜炎。
Am J Ophthalmol. 1998 Jul;126(1):37-41. doi: 10.1016/s0002-9394(98)00071-3.