Nikkhah Homayoon, Ramezani Alireza, Ahmadieh Hamid, Soheilian Masoud, Azarmina Mohsen, Dehghan Mohammad-Hossein, Moradian Siamak, Nourinia Ramin
Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Ophthalmic Vis Res. 2011 Oct;6(4):249-54.
To evaluate the demographic and clinical features of childhood pars planitis, and to determine the therapeutic and visual outcomes of the disease.
Medical records of pediatric patients (less than 16 years of age at diagnosis) with pars planitis and at least 6 months of follow-up who were referred to Labbafinejad Medical Center, Tehran, Iran over a 22 year period were reviewed.
Overall, 117 eyes of 61 patients including 51 (83.6%) male subjects were included. Mean age at the time of diagnosis was 7.8±3.2 (range, 3-16) years. Mean best corrected visual acuity (BCVA) was 0.88±0.76 logMAR at presentation which improved to 0.39±0.51 logMAR at final visit (P<0.001). Endotheliitis was present in 23 (19.6%) eyes and was significantly more prevalent in subjects younger than 9 years (P=0.025). Cataract formation (41.9%) and cystoid macular edema (19.7%) were the most prevalent complications. Univariate regression analysis showed that better baseline visual acuity (OR=0.38, 95%CI 0.21-0.70, P=0.002), age older than 5 years at disease onset (OR=0.36, 95%CI 0.14-0.9, P=0.029), absence of endotheliitis (OR=0.39, 95%CI 0.15-0.99, P=0.047) and female gender (OR=3.77, 95%CI 1.03-13.93, P=0.046) were significantly associated with final BCVA of 20/40 or better.
Childhood pars planitis was much more common among male subjects. Endotheliitis may be a sign of inflammation spillover and is more prevalent in younger patients. Visual prognosis is favorable in most patients with appropriate treatment.
评估儿童睫状体平坦部炎的人口统计学和临床特征，并确定该疾病的治疗效果和视力转归。
回顾了22年间转诊至伊朗德黑兰Labbafinejad医学中心的诊断为睫状体平坦部炎且随访至少6个月的儿科患者（诊断时年龄小于16岁）的病历。
总共纳入了61例患者的117只眼，其中包括51例（83.6%）男性。诊断时的平均年龄为7.8±3.2（范围3 - 16）岁。初诊时平均最佳矫正视力（BCVA）为0.88±0.76 logMAR，末次随访时提高至0.39±0.51 logMAR（P<0.001）。23只眼（19.6%）存在内皮炎症，在9岁以下患者中更为常见（P = 0.025）。白内障形成（41.9%）和黄斑囊样水肿（19.7%）是最常见的并发症。单因素回归分析显示，较好的基线视力（OR = 0.38，95%CI 0.21 - 0.70，P = 0.002）、发病年龄大于5岁（OR = 0.36，95%CI 0.14 - 0.9，P = 0.029）、无内皮炎症（OR = 0.39，95%CI 0.15 - 0.99，P = 0.047）以及女性性别（OR = 3.77，95%CI 1.03 - 13.93，P = 0.046）与最终BCVA达到20/40或更好显著相关。
儿童睫状体平坦部炎在男性中更为常见。内皮炎症可能是炎症扩散的一个迹象，在年轻患者中更普遍。大多数患者经适当治疗后视力预后良好。
