呋塞米对吲哚美辛血药浓度的影响。
The effect of frusemide on indomethacin plasma levels.
机构信息
Centre for Rheumatic Diseases and University Department of Medicine, Royal Infirmary, Glasgow.
出版信息
Br J Clin Pharmacol. 1974 Dec;1(6):485-9. doi: 10.1111/j.1365-2125.1974.tb01698.x.
Abstract
1 The pharmacokinetic and clinical effects of concurrent oral indomethacin and frusemide administration were determined in eight patients with rheumatoid arthritis. 2 Oral frusemide significantly reduces the plasma level of indomethacin following concurrent administration of the two drugs orally. 3 A profile of pain index, articular index and grip strength following oral indomethacin (50 mg) was determined and although the decrease in articular index was less when frusemide and indomethacin were given together it did not reach statistical significance.
摘要
本文旨在探讨类风湿关节炎患者同时口服吲哚美辛和呋塞米时的药代动力学和临床效果。
口服呋塞米可显著降低两种药物同时口服时吲哚美辛的血浆水平。
本文还确定了口服吲哚美辛（50mg）后疼痛指数、关节指数和握力的变化情况，尽管同时给予呋塞米和吲哚美辛时关节指数的下降幅度较小，但无统计学意义。
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本文引用的文献
1
DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association.类风湿关节炎的诊断标准：美国风湿病协会委员会1958年修订版。
Ann Rheum Dis. 1959 Mar;18(1):49-51; French transl 51-2; Spanish transl 52-3.
2
The renal excretion of indomethacin and its inhibition by probenecid.
Clin Pharmacol Ther. 1968 Jan-Feb;9(1):89-93. doi: 10.1002/cpt19689189.
3
4
5
Pharmacokinetics of orally administered furosemide.
Clin Pharmacol Ther. 1974 Feb;15(2):178-86.
6
Simultaneous pharmacokinetics of indomethacin in serum and synovial fluid.吲哚美辛在血清和滑液中的同步药代动力学。
Ann Rheum Dis. 1973 Sep;32(5):433-5. doi: 10.1136/ard.32.5.433.
7
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