Centre for Rheumatic Diseases and University Department of Medicine, Royal Infirmary, Glasgow.
Br J Clin Pharmacol. 1974 Dec;1(6):485-9. doi: 10.1111/j.1365-2125.1974.tb01698.x.
1 The pharmacokinetic and clinical effects of concurrent oral indomethacin and frusemide administration were determined in eight patients with rheumatoid arthritis. 2 Oral frusemide significantly reduces the plasma level of indomethacin following concurrent administration of the two drugs orally. 3 A profile of pain index, articular index and grip strength following oral indomethacin (50 mg) was determined and although the decrease in articular index was less when frusemide and indomethacin were given together it did not reach statistical significance.
本文旨在探讨类风湿关节炎患者同时口服吲哚美辛和呋塞米时的药代动力学和临床效果。
口服呋塞米可显著降低两种药物同时口服时吲哚美辛的血浆水平。
本文还确定了口服吲哚美辛（50mg）后疼痛指数、关节指数和握力的变化情况，尽管同时给予呋塞米和吲哚美辛时关节指数的下降幅度较小，但无统计学意义。
