Cicuttini F M, Spector T D
Department of Rheumatology, St Thomas's Hospital, London, England.
Drugs Aging. 1995 May;6(5):409-20. doi: 10.2165/00002512-199506050-00007.
Osteoarthritis (OA) is the most common of the arthropathies. The prevalence increases significantly with age, with as many as 68% of women and 58% of men aged 65 years or older having radiological evidence of disease. With an aging population, OA will represent an increasingly significant healthcare burden. The current treatment of patients with OA is purely symptomatic. As yet, there is no evidence that treatment changes the course of the disease. The current optimal treatment involves a combined approach which includes modification of risk factors, particularly obesity, and nonpharmacological treatments such as physiotherapy. If drugs are required in the treatment of OA, full dose regular paracetamol (acetaminophen) should be the first line of analgesic therapy. There is little evidence that the current over-reliance on long term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) is justified. If NSAIDs are used, it is necessary to regularly review their use and to be aware of their potential toxicity, particularly in the older age group.
骨关节炎（OA）是最常见的关节病。患病率随年龄显著增加，65岁及以上的女性中有多达68%、男性中有58%有该病的影像学证据。随着人口老龄化，骨关节炎将成为日益严重的医疗负担。目前对骨关节炎患者的治疗纯粹是对症治疗。迄今为止，尚无证据表明治疗能改变疾病进程。当前的最佳治疗方法是综合治疗，包括改变危险因素，尤其是肥胖，以及非药物治疗，如物理治疗。如果骨关节炎治疗需要用药，全剂量常规对乙酰氨基酚应作为镇痛治疗的一线用药。几乎没有证据表明目前过度依赖非甾体抗炎药（NSAIDs）进行长期治疗是合理的。如果使用NSAIDs，有必要定期评估其使用情况，并了解其潜在毒性，尤其是在老年人群体中。
