对乙酰氨基酚不同制剂的生物利用度。
Bioavailability of different preparations of paracetamol.
机构信息
Department of Pharmacology, St Thomas's Hospital Medical School, London.
出版信息
Br J Clin Pharmacol. 1974 Dec;1(6):495-8. doi: 10.1111/j.1365-2125.1974.tb01700.x.
Abstract
1 Plasma drug concentrations in eight volunteer subjects following oral administration of six preparations of paracetamol have been studied. 2 Significant interindividual differences in plasma paracetamol concentration were found within 1 h but there were no consistent differences between the different drug preparations. The results indicate that all the preparations have equivalent bioavailability. 3 In four subjects, tested with the same preparation on two occasions, the findings suggest that drug absorption may differ from one occasion to another.
摘要
8 位志愿者受试者口服 6 种扑热息痛制剂后，研究了其血浆药物浓度。
在 1 小时内发现了个体间血浆扑热息痛浓度的显著差异，但不同药物制剂之间没有一致的差异。结果表明，所有制剂的生物利用度相当。
在 4 位受试者中，两次使用相同制剂进行测试，结果表明药物吸收可能在不同时间有所不同。
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