Chen Jing, Liao Yan, Zhang Hong-zhong, Zhao Hong, Chen Jie, Li Hai-qi
Department of Primary Child Care, Chongqing Medical University, Chongqing, China.
Zhonghua Er Ke Za Zhi. 2012 Jan;50(1):5-9.
To estimate the prevalence and clinical features of food allergy in children aged 0 - 2 years.
From January to February, 2009 and January to May, 2010, all well-infants and young children between the age of 0 and 2 years attending routine health visits at the Department of Primary Child Care, in Chongqing, Zhuhai and Hangzhou were invited to participate in the study. Parents completed questionnaires and all children were skin prick tested (SPT) to a panel of 10 foods (egg white, egg yolk, cow's milk, soybean, peanut, wheat, fish, shrimp, orange and carrot). Based on the results of SPT and medical history, the subjects under went the suspected food elimination and oral food challenge under medical supervision. Food allergy was confirmed by the food challenge test.
Totally 1687 children were recruited by the consent of their parents. Of 1687 children approached, 1604 (550 of Chongqing, 573 of Zhuhai and 481 of Hangzhou) fulfilled the study criteria for diagnosing food allergy. One hundred children were confirmed to have challenge-proven food allergy in 3 cities (40 of Chongqing, 33 of Zhuhai and 27 of Hangzhou). The prevalence of food allergy in 0-2 years old children in Chongqing was 7.3%, in Zhuhai was 5.8% and in Hangzhou was 5.5%. There was no significant difference in the prevalence of food allergy in children under 2 years among the three cities, and the average prevalence for food allergy in children under 2 years was 6.2%. Egg (3.0% - 4.4%) was the most common allergen, followed by cow's milk (0.83% - 3.5%), shrimp (0.17% - 0.42%) and fish (0.17% - 0.21%).
The prevalence of food allergy in 0 - 2 years old children in China was 5.5% - 7.3%. There was no significant difference in the prevalence of food allergy in children under 2 years of age among the three cities. Egg was the most common allergen, followed by cow's milk, shrimp and fish.
评估0至2岁儿童食物过敏的患病率及临床特征。
在2009年1月至2月以及2010年1月至5月期间，邀请重庆市、珠海市和杭州市儿童初级保健科接受常规健康检查的所有0至2岁健康婴幼儿参与研究。家长填写问卷，所有儿童均接受针对10种食物（蛋清、蛋黄、牛奶、大豆、花生、小麦、鱼、虾、橙子和胡萝卜）的皮肤点刺试验（SPT）。根据SPT结果和病史，受试者在医学监督下进行可疑食物排除和口服食物激发试验。通过食物激发试验确诊食物过敏。
经家长同意，共招募了1687名儿童。在1687名儿童中，1604名（重庆550名、珠海573名、杭州481名）符合食物过敏诊断研究标准。三个城市共有100名儿童经激发试验确诊为食物过敏（重庆40名、珠海33名、杭州27名）。重庆0至2岁儿童食物过敏患病率为7.3%，珠海为5.8%，杭州为5.5%。三个城市2岁以下儿童食物过敏患病率无显著差异，2岁以下儿童食物过敏平均患病率为6.2%。鸡蛋（3.0% - 4.4%）是最常见的过敏原，其次是牛奶（0.83% - 3.5%）、虾（0.17% - 0.42%）和鱼（0.17% - 0.21%）。
中国0至2岁儿童食物过敏患病率为5.5% - 7.3%。三个城市2岁以下儿童食物过敏患病率无显著差异。鸡蛋是最常见的过敏原，其次是牛奶、虾和鱼。
