Green M, Brayer A F, Schenkman K A, Wald E R
University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, PA 15213.
Pediatr Infect Dis J. 1989 Sep;8(9):601-5. doi: 10.1097/00006454-198909000-00007.
To describe the typical hospital course of infection in previously well infants hospitalized with respiratory syncytial virus (RSV) infection, we reviewed the charts of 196 patients with laboratory-proved respiratory syncytial virus infection in the 1987-1988 respiratory disease season. Eighty-seven of the children had been previously well. Their mean duration of hospitalization was 3.4 days. Previously well infants younger than 6 weeks of age experienced significantly longer hospitalizations and more days of supplemental oxygen and were more likely to require intensive care than were older children. Children older than 12 weeks of age were hospitalized for a mean of 2.5 days and did not require intensive care. Oxygen saturation was measured in the emergency room for 67 of the previously well infants; in 42 oxygen saturation was at least 90% whereas in 25 saturation was less than 90% or infants were receiving supplemental oxygen at the time of measurement. Decreased initial oxygen saturation was associated with a prolonged hospitalization (5.3 vs. 3.2 days, P less than 0.01) and with more days of supplemental oxygen (4.4 vs. 1.5 days, P less than 0.01). We conclude that among previously well infants admitted to the hospital with respiratory syncytial virus infection, infants younger than 6 weeks of age are at increased risk for a prolonged and more severe hospital course than are older children.
为描述既往健康的婴儿因呼吸道合胞病毒（RSV）感染住院后的典型病程，我们回顾了196例在1987 - 1988年呼吸道疾病季节经实验室证实为呼吸道合胞病毒感染患者的病历。其中87名儿童既往健康。他们的平均住院时间为3.4天。6周龄以下既往健康的婴儿住院时间显著更长，吸氧天数更多，且比年龄较大的儿童更有可能需要重症监护。12周龄以上的儿童平均住院2.5天，不需要重症监护。对67名既往健康的婴儿在急诊室测量了血氧饱和度；其中42名婴儿的血氧饱和度至少为90%，而25名婴儿的血氧饱和度低于90%或在测量时正在接受吸氧。初始血氧饱和度降低与住院时间延长（5.3天对3.2天，P<0.01）以及吸氧天数增加（4.4天对1.5天，P<0.01）相关。我们得出结论，在因呼吸道合胞病毒感染入院的既往健康的婴儿中，6周龄以下的婴儿比年龄较大的儿童有更长且更严重病程的风险增加。
