Technische Universität Berlin, Institut für Chemie Fakultät II, Sekretariat C3 Strasse des 17. Juni 135, 10623, Berlin, Germany.
Chem Soc Rev. 2012 Jun 21;41(12):4389-408. doi: 10.1039/c2cs15348c. Epub 2012 Mar 28.
Since the discovery of metathesis as an instrument to reorganize olefinic double bonds, substantial progress has been attained, establishing this method as a versatile and efficient tool for C-C-bond formation. In the last decade fundamental achievements were accomplished in the field of chiral Ru- and Mo-based olefin metathesis, providing an asymmetric access to structures, which are difficult to obtain by alternative routes. The reader is taken behind the scenes of catalyst development, important areas of application are described up to the current state of research; this tutorial review deals with the question, how metathesis is connected to enantioselective synthesis.
自从发现易位反应可以重组烯烃双键以来，已经取得了实质性的进展，使该方法成为 C-C 键形成的一种通用且有效的工具。在过去的十年中，在手性 Ru 和 Mo 基烯烃复分解领域取得了重大进展，为通过其他途径难以获得的结构提供了不对称途径。读者将深入了解催化剂开发的幕后情况，描述重要的应用领域，直到目前的研究现状；本综述讨论了复分解反应如何与对映选择性合成相关联的问题。
