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高 Z-选择性和对映选择性的开环/交叉复分解反应，由手性钌配合物催化。

Highly Z-selective and enantioselective ring-opening/cross-metathesis catalyzed by a resolved stereogenic-at-Ru complex.

机构信息

Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

出版信息

J Am Chem Soc. 2013 Jul 17;135(28):10183-5. doi: 10.1021/ja4046422. Epub 2013 Jul 3.

DOI:10.1021/ja4046422
PMID:23822901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3826570/
Abstract

The synthesis of a ruthenium complex that catalyzes Z-selective (up to 98% Z) asymmetric ring-opening/cross-metathesis with high enantioselectivity (up to 95% ee) is reported. The synthesis of the catalyst features the resolution of a chelating N-heterocyclic carbene complex by ligand substitution with a chiral carboxylate.

摘要

报道了一种钌配合物的合成方法，该配合物能够催化 Z-选择性（高达 98% Z）的不对称开环/交叉复分解反应，具有高对映选择性（高达 95%ee）。催化剂的合成特点是通过手性羧酸酯的配体取代作用拆分螯合 N-杂环卡宾配合物。

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Z- and enantioselective ring-opening/cross-metathesis with enol ethers catalyzed by stereogenic-at-Ru carbenes: reactivity, selectivity, and Curtin-Hammett kinetics.手性钌卡宾催化的 Z-和对映选择性环开/交叉复分解反应与烯醇醚：反应性、选择性和 Curtin-Hammett 动力学。
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