School of Dental Medicine, University of Connecticut Health Center Farmington, CT 06030, USA.
Biomed Mater. 2012 Apr;7(2):024105. doi: 10.1088/1748-6041/7/2/024105. Epub 2012 Mar 29.
Injectable in situ crosslinkable gels are highly desirable clinically as they can be introduced into a body via a minimally invasive manner using endoscopic or percutaneous procedures. Several hydrophilic polymeric systems that respond to stimuli such as light, temperature, pH, ionic concentration as well as those that can undergo chemical reactions to form crosslinked matrices are currently under development. This paper discusses the applications of hydrogels as scaffolds to mimic the native extracellular matrix of bone and cartilage. A comprehensive description of various gelation methods used in hydrogel preparation and their application as injectable cell and protein delivery vehicle for bone and cartilage regeneration is also presented.
可注射的原位交联凝胶在临床上非常理想，因为它们可以通过内窥镜或经皮手术以微创的方式引入体内。目前正在开发几种对光、温度、pH 值、离子浓度等刺激做出响应的亲水性聚合物系统，以及可以通过化学反应形成交联基质的系统。本文讨论了水凝胶作为支架的应用，以模拟骨和软骨的天然细胞外基质。还全面描述了用于水凝胶制备的各种凝胶化方法及其作为骨和软骨再生的可注射细胞和蛋白质递送载体的应用。
