组织工程在关节软骨修复与再生中的作用。
The role of tissue engineering in articular cartilage repair and regeneration.
作者信息
Zhang Lijie, Hu Jerry, Athanasiou Kyriacos A
机构信息
Department of Biomedical Engineering, University of California, Davis, California 95616, USA.
出版信息
Crit Rev Biomed Eng. 2009;37(1-2):1-57. doi: 10.1615/critrevbiomedeng.v37.i1-2.10.
Abstract
Articular cartilage repair and regeneration continue to be largely intractable because of the poor regenerative properties of this tissue. The field of articular cartilage tissue engineering, which aims to repair, regenerate, and/or improve injured or diseased articular cartilage functionality, has evoked intense interest and holds great potential for improving articular cartilage therapy. This review provides an overall description of the current state of and progress in articular cartilage repair and regeneration. Traditional therapies and related problems are introduced. More importantly, a variety of promising cell sources, biocompatible tissue engineered scaffolds, scaffoldless techniques, growth factors, and mechanical stimuli used in current articular cartilage tissue engineering are reviewed. Finally, the technical and regulatory challenges of articular cartilage tissue engineering and possible future directions are also discussed.
摘要
由于关节软骨组织的再生能力较差，关节软骨修复和再生在很大程度上仍然难以解决。关节软骨组织工程领域旨在修复、再生和/或改善受损或患病关节软骨的功能，引起了人们的浓厚兴趣，并在改善关节软骨治疗方面具有巨大潜力。本文综述了关节软骨修复和再生的现状及进展。介绍了传统疗法及相关问题。更重要的是，对当前关节软骨组织工程中使用的各种有前景的细胞来源、生物相容性组织工程支架、无支架技术、生长因子和机械刺激进行了综述。最后，还讨论了关节软骨组织工程的技术和监管挑战以及可能的未来发展方向。
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