Department of Orthopedics, Zhuji People's Hospital, Shaoxing, Zhejiang, China.
Department of Traumatic Orthopedics, Affiliated Jinan Third Hospital of Jining Medical University, Jinan, Shandong, China.
Drug Deliv. 2022 Dec;29(1):1631-1647. doi: 10.1080/10717544.2022.2075983.
Primary bone tumors especially, sarcomas affect adolescents the most because it originates from osteoblasts cells responsible for bone growth. Chemotherapy, surgery, and radiation therapy are the most often used clinical treatments. Regrettably, surgical resection frequently fails to entirely eradicate the tumor, which is the primary cause of metastasis and postoperative recurrence, leading to a high death rate. Additionally, bone tumors frequently penetrate significant regions of bone, rendering them incapable of self-repair, and impairing patients' quality of life. As a result, treating bone tumors and regenerating bone in the clinic is difficult. In recent decades, numerous sorts of alternative therapy approaches have been investigated due to a lack of approved treatments. Among the novel therapeutic approaches, hydrogel-based anticancer therapy has cleared the way for the development of new targeted techniques for treating bone cancer and bone regeneration. They include strategies such as co-delivery of several drug payloads, enhancing their biodistribution and transport capabilities, normalizing accumulation, and optimizing drug release profiles to decrease the limitations of current therapy. This review discusses current advances in functionalized hydrogels to develop a new technique for treating bone tumors by reducing postoperative tumor recurrence and promoting tissue repair.
原发性骨肿瘤，尤其是肉瘤，对青少年的影响最大，因为它起源于成骨细胞，这些细胞负责骨骼生长。化疗、手术和放射疗法是最常用的临床治疗方法。遗憾的是，手术切除常常无法完全根除肿瘤，这是转移和术后复发的主要原因，导致高死亡率。此外，骨肿瘤经常穿透骨骼的重要区域，使其无法自我修复，并损害患者的生活质量。因此，在临床上治疗骨肿瘤和再生骨骼具有一定难度。近几十年来，由于缺乏批准的治疗方法，人们研究了许多种替代治疗方法。在新的治疗方法中，基于水凝胶的抗癌疗法为开发治疗骨癌和骨再生的新靶向技术铺平了道路。这些策略包括共递几种药物有效载荷、增强其生物分布和运输能力、使药物正常积累、优化药物释放曲线，以减少当前治疗方法的局限性。本文综述了功能化水凝胶在减少术后肿瘤复发和促进组织修复方面治疗骨肿瘤的新技术的研究进展。
