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强畸胎癌移植位点Gt-1和Gt-2位于H-2侧翼。

Strong teratocarcinoma transplantation loci, Gt-1 and Gt-2, flank H-2.

作者信息

Shedlovsky A, Clipson L J, VandeBerg J L, Dove W F

出版信息

Immunogenetics. 1981;13(5):413-9. doi: 10.1007/BF00346022.

DOI:10.1007/BF00346022
PMID:7298086
Abstract

Evidence is presented for the existence of two strong murine teratocarcinoma transplantation antigens (Gt) on the cell line PCC3. It is shown that the loci governing expression of these antigens are linked to the H-2 complex. These loci have been further mapped with respect to the brachyury marker (T) and H-2: Gt-1 lies 5 +/- 2 crossover units proximal to H-2 and 12 +/- 2 crossover units distal to T; Gt-2 lies 21 +/- 4 crossover units distal to H-2. It is possible that these strong transplantation antigens provide an embryonic analogue to the adult major histocompatibility system.

摘要

有证据表明,在细胞系PCC3上存在两种强大的小鼠畸胎瘤移植抗原(Gt)。结果表明,控制这些抗原表达的基因座与H-2复合体相连。这些基因座已根据短尾标记(T)和H-2进一步定位:Gt-1位于H-2近端5±2个交换单位处,T远端12±2个交换单位处;Gt-2位于H-2远端21±4个交换单位处。这些强大的移植抗原可能为成年主要组织相容性系统提供一种胚胎类似物。

相似文献

1
Strong teratocarcinoma transplantation loci, Gt-1 and Gt-2, flank H-2.强畸胎癌移植位点Gt-1和Gt-2位于H-2侧翼。
Immunogenetics. 1981;13(5):413-9. doi: 10.1007/BF00346022.
2
Teratocarcinoma transplantation antigens are encoded in the H-2 region.畸胎癌移植抗原是在H-2区域编码的。
Immunogenetics. 1983;18(2):137-45. doi: 10.1007/BF00368542.
3
Teratocarcinoma transplantation rejection loci: genetic localization of the Gt-1 locus on chromosome 17 and the expression of alternate alleles.畸胎癌移植排斥位点:17号染色体上Gt-1位点的基因定位及等位基因的表达
Immunogenetics. 1981;13(5):405-12. doi: 10.1007/BF00346021.
4
Mice coisogenically immunized against H-2 class I antigens on transfected L cells reject transplanted embryonal carcinoma cells.在转染的L细胞上针对H-2 I类抗原进行同基因免疫的小鼠会排斥移植的胚胎癌细胞。
Immunogenetics. 1985;22(6):533-41. doi: 10.1007/BF00430301.
5
Resistance to murine 402AX teratocarcinoma: regulation by H-2IA and H-3 to H-13 region genes.对小鼠402AX畸胎癌的抗性:由H-2IA以及H-3至H-13区域基因调控。
Immunogenetics. 1984;19(1):77-82. doi: 10.1007/BF00364477.
6
Genetics of teratocarcinoma transplantation. III. Genetic control of resistance to F9 tumor formation in allogeneic hosts.畸胎癌移植的遗传学。III. 同种异体宿主中对F9肿瘤形成抗性的遗传控制。
J Reprod Immunol. 1982 Feb;4(1):31-7. doi: 10.1016/0165-0378(82)90021-3.
7
H-2 class I antigen expression on mouse teratocarcinoma cell lines.小鼠畸胎瘤细胞系上的H-2 I类抗原表达
Immunogenetics. 1985;22(6):543-52. doi: 10.1007/BF00430302.
8
H-2 antigen expression on teratocarcinoma cells passaged in genetically resistant mice is regulated by lymphoid cells.在基因抗性小鼠中传代的畸胎癌细胞上的H-2抗原表达受淋巴细胞调控。
Proc Natl Acad Sci U S A. 1981 Nov;78(11):7106-10. doi: 10.1073/pnas.78.11.7106.
9
Studies in histocompatibility.组织相容性研究
Science. 1981 Jul 10;213(4504):172-8. doi: 10.1126/science.7017931.
10
Immunogenic cell variants of a mouse teratocarcinoma confer a protection against the original non-immunogenic transplantable tumor.小鼠畸胎癌的免疫原性细胞变体可对原始的非免疫原性可移植肿瘤起到保护作用。
Eur J Cancer Clin Oncol. 1981 Oct;17(10):1083-7. doi: 10.1016/0014-2964(81)90292-9.

引用本文的文献

1
Teratocarcinoma transplantation rejection loci: genetic localization of the Gt-1 locus on chromosome 17 and the expression of alternate alleles.畸胎癌移植排斥位点:17号染色体上Gt-1位点的基因定位及等位基因的表达
Immunogenetics. 1981;13(5):405-12. doi: 10.1007/BF00346021.
2
Minor histocompatibility antigen expression on F9 embryonal carcinoma cells revealed by T-cell mediated responses.通过T细胞介导的反应揭示F9胚胎癌细胞上的次要组织相容性抗原表达。
Immunogenetics. 1982;16(4):349-54. doi: 10.1007/BF00372306.
3
H-2 haplotypes, genes, and antigens: second listing. I. Non-H-2 loci on chromosome 17.

本文引用的文献

1
Susceptibility of allogeneic mice to teratocarcinoma 402AX.同种异体小鼠对畸胎癌402AX的易感性。
Immunogenetics. 1980;10(6):607-12. doi: 10.1007/BF01572595.
2
Semisyngeneic hybrid resistance to murine teratocarcinoma cells.对半同基因杂种对鼠胚癌细胞的抗性。
Immunogenetics. 1980;10(4):383-93. doi: 10.1007/BF01561588.
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Relationship of F9 antigen and genes of theT/t complex.F9 抗原与 T/t 复合体基因的关系。
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Overt expression of H-2 serotypes on EC cells is not necessary for host rejection.EC细胞上H-2血清型的过度表达对于宿主排斥反应并非必需。
Immunogenetics. 1984;19(4):343-7. doi: 10.1007/BF00345407.
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Male-specific transplantation antigen expression by XY teratocarcinomas PCC7 and 7'.XY 畸胎癌 PCC7 和 7' 的雄性特异性移植抗原表达
Immunogenetics. 1984;19(3):233-41. doi: 10.1007/BF00364766.
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Teratocarcinoma transplantation antigens are encoded in the H-2 region.畸胎癌移植抗原是在H-2区域编码的。
Immunogenetics. 1983;18(2):137-45. doi: 10.1007/BF00368542.
7
H-2 class I antigen expression on mouse teratocarcinoma cell lines.小鼠畸胎瘤细胞系上的H-2 I类抗原表达
Immunogenetics. 1985;22(6):543-52. doi: 10.1007/BF00430302.
8
Mice coisogenically immunized against H-2 class I antigens on transfected L cells reject transplanted embryonal carcinoma cells.在转染的L细胞上针对H-2 I类抗原进行同基因免疫的小鼠会排斥移植的胚胎癌细胞。
Immunogenetics. 1985;22(6):533-41. doi: 10.1007/BF00430301.
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Analysis of the xenogeneic T-cell response to murine H-2 negative embryonal carcinoma cells.对小鼠H-2阴性胚胎癌细胞的异种T细胞反应分析。
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Differential Hm antigen expression on EC cells and early differentiated derivatives.EC细胞和早期分化衍生物上Hm抗原的差异表达。
EMBO J. 1985 May;4(5):1177-85. doi: 10.1002/j.1460-2075.1985.tb03757.x.
Immunogenetics. 1978 Dec;7(1):337-47. doi: 10.1007/BF01844023.
4
The genetics of teratocarcinoma transplantation: tumor formation in allogeneic hosts by the embryonal carcinoma cell lines F9 and PCC3.畸胎癌移植的遗传学:胚胎癌细胞系 F9 和 PCC3 在同种异体宿主中的肿瘤形成。
Immunogenetics. 1978 Dec;7(1):103-15. doi: 10.1007/BF01843995.
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The genetics of transplantation.移植遗传学。
J Natl Cancer Inst. 1953 Dec;14(3):691-700; discussion, 701-4.
6
Cell surfaces and embryos: expression of the F9 teratocarcinoma antigen in T-region lethal, other lethal, and normal pre-implantation mouse embryos.细胞表面与胚胎:F9畸胎瘤抗原在T区域致死、其他致死及正常着床前小鼠胚胎中的表达
J Reprod Immunol. 1980 Dec;2(5):293-304. doi: 10.1016/0165-0378(80)90042-x.
7
Natural killer cells mediate lysis of embryonal carcinoma cells lacking MHC.自然杀伤细胞介导对缺乏主要组织相容性复合体(MHC)的胚胎癌细胞的裂解作用。
Nature. 1980 May 29;285(5763):341-2. doi: 10.1038/285341a0.
8
Teratocarcinoma transplantation rejection loci: genetic localization of the Gt-1 locus on chromosome 17 and the expression of alternate alleles.畸胎癌移植排斥位点:17号染色体上Gt-1位点的基因定位及等位基因的表达
Immunogenetics. 1981;13(5):405-12. doi: 10.1007/BF00346021.
9
Immune response of mice to Thy-1. 1 antigen: genetic control by alleles at the Ir-5 locus loosely linked to the H-2 complex.小鼠对Thy-1.1抗原的免疫反应:由与H-2复合体松散连锁的Ir-5位点上等位基因进行的遗传控制。
J Immunol. 1974 Oct;113(4):1170-7.
10
Genetic control of the immune response. Mapping of the Ir-1 locus.免疫反应的遗传控制。Ir-1基因座的定位。
J Exp Med. 1972 Jun 1;135(6):1259-78. doi: 10.1084/jem.135.6.1259.