F9 抗原与 T/t 复合体基因的关系。

Relationship of F9 antigen and genes of theT/t complex.

机构信息

Laboratory for Developmental Genetics, Sloan-Kettering Institute for Cancer Research, 10021, New York, New York.

出版信息

Immunogenetics. 1978 Dec;7(1):337-47. doi: 10.1007/BF01844023.

PMID:21302088

Abstract

Serological studies relating F9 antigen of embryonal carcinoma cells to[Formula: see text] at the murineT/t complex have been extended and confirm that only the lethal haplotype t(12)- and none of the other five lethal haplotypes-affects the quantitative expression of F9 antigen on sperm. Cytotoxicity tests on preimplantation embryos show that t(12) homozygotes are less susceptible to antiF9 serum than t(w5) homozygotes, and that using specific antimutant haplotype antisera prepared against sperm, t(12) antigen is detectable on morulae, whereas t(w5) antigen is not.

摘要

关于胚胎癌细胞 F9 抗原与鼠 T/t 复合体上的[Formula: see text]之间关系的血清学研究已经得到扩展，并证实只有致死单倍型 t(12)-而不是其他五个致死单倍型-影响精子上 F9 抗原的定量表达。对着床前胚胎的细胞毒性试验表明，t(12)纯合子比 t(w5)纯合子对抗 F9 血清的敏感性更低，并且使用针对精子制备的特异性抗突变单倍型抗血清，t(12)抗原可在桑葚胚上检测到，而 t(w5)抗原则不能。