Cuneo R C, Salomon F, Wiles C M, Sönksen P H
Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.
Horm Res. 1990;33 Suppl 4:55-60. doi: 10.1159/000181585.
Skeletal muscle mass and function were assessed in 24 adults (16 males, 8 females) with severe, long-standing GH deficiency. Compared to 41 untrained controls (26 males, 15 females), adults with GH deficiency had reduced cross-sectional area of thigh muscle/body weight (p = 0.01), reduced quadriceps force/weight (males: p = 0.002; females: p less than 0.0001), and reduced quadriceps force/muscle area (males: p = 0.005). This suggests (a) that adults with GH deficiency have reduced skeletal muscle mass due, in part, to the absence of the anabolic effects of GH, and (b) that skeletal muscle force may be reduced due to altered muscle mass, contractile elements/muscle fibre, anaerobic energy supply, neural recruitment of fibres, or a combination of these.
对24名患有严重、长期生长激素缺乏症的成年人（16名男性，8名女性）的骨骼肌质量和功能进行了评估。与41名未经训练的对照组（26名男性，15名女性）相比，生长激素缺乏的成年人的大腿肌肉横截面积/体重降低（p = 0.01），股四头肌力量/体重降低（男性：p = 0.002；女性：p < 0.0001），股四头肌力量/肌肉面积降低（男性：p = 0.005）。这表明：（a）生长激素缺乏的成年人骨骼肌质量降低，部分原因是缺乏生长激素的合成代谢作用；（b）骨骼肌力量可能因肌肉质量、收缩元件/肌纤维、无氧能量供应、神经纤维募集的改变或这些因素的综合作用而降低。
