miRNA 的降解和周转：调控调控者。
MicroRNA degradation and turnover: regulating the regulators.
机构信息
Department of Cardiology, Changhai Hospital, Shanghai, China.
出版信息
Wiley Interdiscip Rev RNA. 2012 Jul-Aug;3(4):593-600. doi: 10.1002/wrna.1114. Epub 2012 Mar 28.
Abstract
MicroRNAs (miRNAs) are endogenous, small noncoding RNAs that play important regulatory roles in gene expression. The control of miRNA biogenesis has been well characterized, but their degradation is not fully understood. Recent discoveries indicate that miRNAs have a long life span in general. However, rapid turnover dynamics of miRNAs in a variety of specific cellular contexts has been documented, as well as the requirement of sequence elements for miRNA decay. Furthermore, several ribonucleases that degrade miRNAs have been identified. Here, we discuss the cellular contexts and biochemical mechanisms of miRNA decay, together with several prominent questions in this field.
摘要
MicroRNAs (miRNAs) 是内源性的小型非编码 RNA，在基因表达中发挥重要的调节作用。miRNA 的生物发生调控已得到很好的描述，但它们的降解过程还不完全清楚。最近的发现表明，miRNAs 通常具有较长的寿命。然而，在各种特定的细胞环境中，miRNAs 的快速周转动态已经得到了记录，并且需要序列元件来进行 miRNA 的降解。此外，已经鉴定出几种能够降解 miRNA 的核糖核酸酶。在这里，我们讨论了 miRNA 降解的细胞环境和生化机制，以及该领域的几个突出问题。
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2
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3
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