紫外线照射的人巨细胞病毒对仓鼠胚胎成纤维细胞的转化
Transformation of hamster embryonic fibroblast cells by UV-irradiated human cytomegalovirus.
作者信息
Boldogh I, Gönczöl E, Váczi L
出版信息
Acta Microbiol Acad Sci Hung. 1978;25(4):269-75.
Infection of hamster embryonic fibroblast (HEF) cells with UV-irradiated human CMV resulted in appearance of transformed clones. The established cell line (87-TRH-5) when inoculated subcutaneously induced tumour in newborn hamsters. The 87-TRH-5 cell line and the cell lines (87-TRH-5-Tsc1, 87-TRH-5-Tsc2, 87TRH-5-Tsc3) developed from the induced tumour, proved to bear CMV-spcific cytoplasmic and surface antigens. Demonstration of infectious CMV or MCV-specific nuclear antigen in 87-THR-5-cells has failed.
用紫外线照射过的人巨细胞病毒感染仓鼠胚胎成纤维细胞（HEF），导致出现转化克隆。建立的细胞系（87-TRH-5）皮下接种新生仓鼠时可诱发肿瘤。从诱发肿瘤中培养出的87-TRH-5细胞系以及细胞系（87-TRH-5-Tsc1、87-TRH-5-Tsc2、87TRH-5-Tsc3），被证明带有巨细胞病毒特异性细胞质和表面抗原。在87-THR-5细胞中未能检测到传染性巨细胞病毒或巨细胞病毒特异性核抗原。
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