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C57BL/6J小鼠的巴甫洛夫双条件辨别学习

Pavlovian biconditional discrimination learning in the C57BL/6J mouse.

作者信息

Ramirez Jason J, Colwill Ruth M

机构信息

Department of Psychology, Brown University, Providence, RI 02912, United States. jason

出版信息

Behav Processes. 2012 Jun;90(2):278-86. doi: 10.1016/j.beproc.2012.02.017. Epub 2012 Mar 23.

DOI:10.1016/j.beproc.2012.02.017
PMID:22465263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3348442/
Abstract

Four experiments using mice examined acquisition of Pavlovian biconditional discriminations in which two stimulus compounds were paired with food (AX+ and BY+) and two were not (AY- and BX-). Temporally asynchronous compounds were generated by using contextual stimuli (Experiment 1) and 15-s discrete visual cues (Experiments 2A, 2B and 3) to disambiguate when embedded noise or tone stimuli would be paired with food. When food pellets followed both reinforced compounds, successful acquisition was obtained in Experiment 1 but not in Experiments 2A and 2B even though the order of trials was modeled after that used in Experiment 1. However, when differential outcomes followed the reinforced compounds in Experiment 3, acquisition was obtained with discrete cue stimulus compounds. The implications of these results for modulatory models of conditional discrimination learning in animals are discussed.

摘要

四项以小鼠为对象的实验研究了巴甫洛夫双条件辨别学习的获得情况,其中两种刺激复合物与食物配对(AX+和BY+),另外两种则不与食物配对(AY-和BX-)。通过使用情境刺激(实验1)和15秒的离散视觉线索(实验2A、2B和3)来生成时间异步复合物,以便在嵌入的噪声或音调刺激与食物配对时进行区分。当食物颗粒紧跟在两种强化复合物之后时,实验1获得了成功的学习成果,但实验2A和2B中却没有,尽管实验顺序是仿照实验1进行的。然而,在实验3中,当强化复合物之后出现不同结果时,使用离散线索刺激复合物获得了学习成果。本文讨论了这些结果对动物条件辨别学习调节模型的意义。

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本文引用的文献

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J Exp Psychol Anim Behav Process. 2010 Oct;36(4):471-81. doi: 10.1037/a0019136.
2
Behavioral flexibility in a mouse model of developmental cerebellar Purkinje cell loss.发育性小脑浦肯野细胞缺失小鼠模型中的行为灵活性。
Neurobiol Learn Mem. 2010 Sep;94(2):220-8. doi: 10.1016/j.nlm.2010.05.010. Epub 2010 Jun 1.
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Genetic dissection of neural circuits and behavior in Mus musculus.小家鼠神经回路与行为的遗传学剖析
Adv Genet. 2009;65:1-38. doi: 10.1016/S0065-2660(09)65001-X.
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Behav Processes. 2008 Mar;77(3):413-27; discussion 451-3. doi: 10.1016/j.beproc.2007.09.013. Epub 2007 Oct 13.
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Elemental representations of stimuli in associative learning.联想学习中刺激的基本表征。
Psychol Rev. 2006 Jul;113(3):584-605. doi: 10.1037/0033-295X.113.3.584.
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