Vicente C, Porto G, de Sousa M
Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal.
J Lab Clin Med. 1990 Dec;116(6):779-84.
A method is described for the establishment of reference values for serum ferritin depending on sex and age. The results obtained in a stratified random sample of 353 healthy individuals from the Portuguese population revealed that 23% of the variation observed on serum ferritin values was related to sex differences and 6% of the variation was explained by age differences. Furthermore, the effect of age was different in both sexes: serum ferritin values increase with age in females over 40 years and in males under 40. The minimum and maximum reference values were established for the different subgroups of subjects as follows: for females under 40 years and males over 40, reference values were considered as the 2.5 and 97.5 percentiles from the adjusted lognormal distribution; for females over 40 years and males under 40, reference values were considered as the exponential transformation of the upper and lower limits of the 95% prediction intervals for the log of serum ferritin for each particular age point.
描述了一种根据性别和年龄建立血清铁蛋白参考值的方法。在来自葡萄牙人群的353名健康个体的分层随机样本中获得的结果显示，血清铁蛋白值观察到的变异中有23%与性别差异有关，6%的变异可由年龄差异解释。此外，年龄对两性的影响不同：40岁以上女性和40岁以下男性的血清铁蛋白值随年龄增加而升高。为不同亚组的受试者建立了如下最小和最大参考值：40岁以下女性和40岁以上男性，参考值被视为来自调整后的对数正态分布的第2.5和第97.5百分位数；40岁以上女性和40岁以下男性，参考值被视为每个特定年龄点血清铁蛋白对数的95%预测区间上下限的指数转换。
