Custer E M, Finch C A, Sobel R E, Zettner A
Department of Pathology, School of Medicine, University of California at San Diego, La Jolla, USA.
J Lab Clin Med. 1995 Jul;126(1):88-94.
The purpose of this study was to establish norms for the serum ferritin determination. Analyses of blood samples submitted for a panel of 29 laboratory tests in 964,325 individuals of a random population of all races in 10 centers in the United States were used. A subgroup of 59,914 ferritin values was constituted from panels that showed the values of the 28 other laboratory tests inside prescribed limits that approached the conventionally used reference ranges. The selected group was taken to be more representative of normal ferritin values than the total group, because in the former group the accompanying 28 other test parameters approached normalcy. Although both groups showed a log-normal distribution of serum ferritin values, the values of the selected group were somewhat lower than those of the total population group. The percentile distribution for men and women of different ages is portrayed. In males, the median ferritin level increased from 23 micrograms/L at ages 12 through 16 years to reach a plateau in the 120s after age 32. Values in females remained in the 30s until menopause, after which values rose to about 80 micrograms/L. The validity of these data and their clinical significance are discussed.
本研究的目的是建立血清铁蛋白测定的规范。我们对美国10个中心所有种族的964,325名随机人群进行了一组29项实验室检测的血样分析。从显示其他28项实验室检测值在规定限度内且接近传统参考范围的检测组中，选取了59,914个铁蛋白值组成一个亚组。所选组被认为比总体组更能代表正常铁蛋白值，因为在前一组中，伴随的其他28项检测参数接近正常。尽管两组血清铁蛋白值均呈对数正态分布，但所选组的值略低于总体组的值。文中描绘了不同年龄男性和女性的百分位数分布情况。在男性中，铁蛋白水平中位数从12至16岁时的23微克/升上升，到32岁后在120多微克/升达到平稳状态。女性的值在绝经前保持在30多微克/升，绝经后升至约80微克/升。文中讨论了这些数据的有效性及其临床意义。
