Wangkheimayum Sujata, Kumar Sunil, Suri Vanita
Indian J Clin Biochem. 2011 Apr;26(2):169-71. doi: 10.1007/s12291-010-0102-2. Epub 2011 Jan 13.
P-selectin, a cell adhesion molecule is elevated in many inflammatory conditions including preeclampsia which is characterized by generalized endothelial dysfunction and vasoconstriction presumably due to free radicals or mediators released by defective placentation. Vitamin E has been documented to protect cell membranes from oxidative damage and also decrease platelet aggregation. The role of vitamin E in pre-eclampsia is contradictory and hence the study was undertaken. Soluble P-selectin was measured by ELISA and Vitamin-E levels in plasma was estimated spectrofluorometrically. In our study the effect of supplementation of 400 IU/day of Vitamin E (a-tocopheryl acetate) to patients of pre-eclampsia showed significant decreased levels of soluble P-selectin by 2nd week as compared to patients given placebo (P = 0.005). In this short period of study no direct correlations were observed between Vitamin E or P-selectin levels with blood pressure as well as with proteinuria. Future studies may focus on the effect of a-tocopheryl acetate or the phosphate form of Vitamin-E, recently proposed to be the more active form on other inflammatory markers like IL-6, an important stimuli of P-selectin release in pre-eclampsia.
P-选择素是一种细胞黏附分子，在包括先兆子痫在内的许多炎症性疾病中水平升高。先兆子痫的特征是全身性内皮功能障碍和血管收缩，这可能是由于胎盘形成缺陷释放的自由基或介质所致。维生素E已被证明可保护细胞膜免受氧化损伤，并减少血小板聚集。维生素E在先兆子痫中的作用存在矛盾，因此开展了这项研究。通过酶联免疫吸附测定法（ELISA）测量可溶性P-选择素，并采用荧光分光光度法估计血浆中的维生素E水平。在我们的研究中，与给予安慰剂的患者相比，先兆子痫患者补充400国际单位/天的维生素E（醋酸α-生育酚），在第2周时可溶性P-选择素水平显著降低（P = 0.005）。在这个短期研究中，未观察到维生素E或P-选择素水平与血压以及蛋白尿之间存在直接相关性。未来的研究可能集中于醋酸α-生育酚或维生素E的磷酸盐形式（最近有人提出这是更具活性的形式）对其他炎症标志物的影响，如白细胞介素-6，它是先兆子痫中P-选择素释放的重要刺激物。
