Yadav Amita, Jyoti Pramila, Jain S K, Bhattacharjee Jayashree
Indian J Clin Biochem. 2011 Apr;26(2):193-6. doi: 10.1007/s12291-011-0119-1. Epub 2011 Feb 18.
The increasing incidence of obesity, leading to metabolic complications is now recognized as a major public-health problem. Insulin resistance is a central abnormality of the metabolic syndrome, or syndrome X, originally hypothesized by Reaven Insulin resistance is more strongly linked to intra abdominal fat than to fat in other depots. Adipose tissue secretes numerous factors (adipokines) known to markedly influence lipid and glucose/insulin metabolism, oxidative stress, and cardiovascular integrity. Some of these adipokines have been shown to directly or indirectly affect insulin sensitivity through modulation of insulin signaling and the molecules involved in glucose and lipid metabolism. A pilot study was conducted with 80 healthy subjects who were non diabetic, non hypertensive and having no family history of hypertension, the aim was to evaluate the correlation of adiponectin and leptin levels with obesity and insulin resistance markers in healthy north Indian adult population. Serum leptin, adiponectin and insulin was estimated by sandwich ELISA method. In our study, Leptin correlated significantly with BMI (P value of 0.0000), WC (P value = 0.007), and HC (P value = 0.000). leptin showed significant positive correlation with fasting insulin (P value 0.002), post prandial insulin (P value = 0.000) and HOMA-IR (P value = 0.002). Adiponectin showed significant positive correlation with triglycerides (P value = 0.038), strong negative correlation with HDL-cholesterol (P value = 0.017). Serum concentrations of leptin are associated with central body fat distribution. Insulin resistance and adiponectin is associated with dyslipidemia and these all disorders may ultimately lead to metabolic syndrome.
肥胖发病率不断上升，导致代谢并发症，如今这已被公认为一个重大的公共卫生问题。胰岛素抵抗是代谢综合征（或X综合征）的核心异常情况，最初由雷文提出。胰岛素抵抗与腹部脂肪的关联比与其他部位脂肪的关联更为紧密。脂肪组织会分泌多种因子（脂肪因子），已知这些因子会显著影响脂质和葡萄糖/胰岛素代谢、氧化应激以及心血管完整性。其中一些脂肪因子已被证明可通过调节胰岛素信号以及参与葡萄糖和脂质代谢的分子，直接或间接影响胰岛素敏感性。对80名健康受试者进行了一项初步研究，这些受试者无糖尿病、无高血压且无高血压家族史，目的是评估健康的印度北部成年人群中脂联素和瘦素水平与肥胖及胰岛素抵抗标志物之间的相关性。采用夹心酶联免疫吸附测定法检测血清瘦素、脂联素和胰岛素。在我们的研究中，瘦素与体重指数（P值为0.0000）、腰围（P值 = 0.007）和臀围（P值 = 0.000）显著相关。瘦素与空腹胰岛素（P值0.002）、餐后胰岛素（P值 = 0.000）和稳态模型评估胰岛素抵抗指数（P值 = 0.002）呈显著正相关。脂联素与甘油三酯呈显著正相关（P值 = 0.038），与高密度脂蛋白胆固醇呈强负相关（P值 = 0.017）。血清瘦素浓度与中心性体脂分布有关。胰岛素抵抗和脂联素与血脂异常有关，而所有这些疾病最终都可能导致代谢综合征。
