Sjöberg F, Thorborg P, Wranne B, Lund N
Department of Anesthesiology, University Hospital, Linköping, Sweden.
Microcirc Endothelium Lymphatics. 1990 Apr-Jun;6(2-3):127-48.
The measuring properties of antimony electrodes were improved by the introduction of highly purified crystallographically oriented monocrystalline antimony (COMA). COMA electrodes are sensitive to pH and pO2. For measurements of either pH, pO2, or both, the pH and the pO2 sensitivities must be known and the components of the composite electrode signal must be separable. The oxygen sensitivity of COMA electrodes in vivo have been shown to be higher than in vitro in the pO2 range below 10 kPa. The present study was performed in an animal model to investigate the oxygen sensitivity and to further evaluate the tissue pO2 measuring properties of a miniaturized six channel COMA microelectrode. The results show that the COMA microelectrode has negligible drift, a response time of less than 5 s and high sensitivity and reproducibility for tissue pO2 measurements when the pH part of the electrode signal is eliminated. The oxygen sensitivity found (8.5 +/- 0.4 (mV/pO2) (mean +/- SEM)), is described by a direct linear function in the oxygen tension range studied. It is concluded that tissue pO2 can be calculated after elimination of the pH part of the electrode signal. A multichannel COMA microelectrode possess characteristics suitable for in vivo oxygen measurements and is therefore an interesting complement to traditional tissue oxygen sensors.
通过引入高度纯化的晶体取向单晶锑（COMA），锑电极的测量性能得到了改善。COMA电极对pH值和pO2敏感。对于pH值、pO2或两者的测量，必须知道pH值和pO2的敏感性，并且复合电极信号的成分必须是可分离的。在低于10 kPa的pO2范围内，已证明COMA电极在体内的氧敏感性高于体外。本研究在动物模型中进行，以研究氧敏感性，并进一步评估小型化六通道COMA微电极的组织pO2测量性能。结果表明，当消除电极信号的pH部分时，COMA微电极的漂移可忽略不计，响应时间小于5 s，对组织pO2测量具有高灵敏度和可重复性。在所研究的氧张力范围内，发现的氧敏感性（8.5 +/- 0.4（mV/pO2）（平均值 +/- 标准误））由直接线性函数描述。得出的结论是，在消除电极信号的pH部分后，可以计算组织pO2。多通道COMA微电极具有适合体内氧测量的特性，因此是传统组织氧传感器的一个有趣补充。
