Sjöberg F, Edwall G, Lund N
Scand J Clin Lab Invest. 1987 Feb;47(1):11-5. doi: 10.1080/00365518709168863.
Monocrystalline micro antimony electrodes in a multipoint arrangement as described by Lund et al. were placed on the skeletal muscle surface of the rabbit. Tissue oxygen levels were measured simultaneously with the MDO (Mehrdraht Dortmund Oberfläche) oxygen electrode. The sensitivity for variations in tissue PO2 (PO2(t)) was evaluated for the antimony metal-metal oxide sensor. The sensitivity (delta E/delta log10 PO2)+/- SE was found to be 21.8 +/- 1.2 mV in the interval between 0.1 kPa and 1 kPa and 53 +/- 5 mV in the interval between 1 kPa and 6 kPa. These results are not consistent with the oxygen sensitivity of monocrystalline antimony described in vitro, but are in agreement with the findings of Nilsson & Edwall. A plausible explanation for the S-shaped oxygen sensitivity curve of antimony at oxygen levels below 10 kPa could be an interaction, at the electrode surface, between the dissolved oxygen and the oxygen bound to haemoglobin. If this is the case, the use of an antimony electrode would make possible the determination of the dissociation of oxyhaemoglobin in tissues.
按照Lund等人所述的多点排列方式，将单晶微锑电极置于家兔骨骼肌表面。同时使用MDO（多特蒙德多线表面）氧电极测量组织氧水平。对锑金属-金属氧化物传感器评估其对组织PO2（PO2(t)）变化的敏感性。在0.1 kPa至1 kPa区间，灵敏度（δE/δlog10 PO2）±标准误为21.8±1.2 mV，在1 kPa至6 kPa区间为53±5 mV。这些结果与体外描述的单晶锑的氧敏感性不一致，但与Nilsson和Edwall的研究结果相符。对于锑在低于10 kPa氧水平下呈S形氧敏感性曲线的一个合理的解释可能是，在电极表面，溶解氧与结合在血红蛋白上的氧之间存在相互作用。如果是这种情况，使用锑电极将有可能测定组织中氧合血红蛋白的解离情况。
