Asif Mohammad, Kumar Arun
Department of Pharmacy, Faculty of Pharmacy, GRD (PG) IMT Rajpur, Dehradun - 248 901, Uttarakhand, India.
J Nat Sci Biol Med. 2011 Jan;2(1):76-9. doi: 10.4103/0976-9668.82315.
The antinociceptive activity of ethanolic extract of the plant bark of Dalbergia sissoo (Roxb.) was investigated using tail flick method on Wistar rats. Three different dose levels (300, 500, and 1000 mg/kg) in 0.5% carboxyl methyl cellulose (CMC) were administered by p.o. route. The antinociceptive activities of the all doses were compared with that of the standard drug asprin (300 mg/kg) administered by p.o. route and the results were found to be significant (P < 0.01). At the above doses, the extract exhibited significant and dose-dependent antinociceptive activity. Phytochemical investigation of the ethanolic extract indicated the presence of carbohydrates, proteins, amino acids, phenolic compounds, and flavanoids. The antinociceptive activity of the bark extract of D. sissoo may be due to the presence of phytochemical constituents such as flavanoids. The acute toxicity study revealed that ethanolic extract was not toxic up to 3000 mg/kg body weight.
采用甩尾法，在Wistar大鼠上研究了印度黄檀（Roxb.）植物树皮乙醇提取物的抗伤害感受活性。通过口服途径给予0.5%羧甲基纤维素（CMC）中的三种不同剂量水平（300、500和1000 mg/kg）。将所有剂量的抗伤害感受活性与口服给予的标准药物阿司匹林（300 mg/kg）进行比较，结果发现具有显著性差异（P < 0.01）。在上述剂量下，提取物表现出显著的剂量依赖性抗伤害感受活性。乙醇提取物的植物化学研究表明存在碳水化合物、蛋白质、氨基酸、酚类化合物和黄酮类化合物。印度黄檀树皮提取物的抗伤害感受活性可能归因于黄酮类等植物化学成分的存在。急性毒性研究表明，乙醇提取物在高达3000 mg/kg体重时无毒。
