未发现英国前列腺癌患者感染 XMRV、BK 病毒、阴道毛滴虫或人乳头瘤病毒。

Division of Virology, MRC National Institute for Medical Research, London, United Kingdom.

PLoS One. 2012;7(3):e34221. doi: 10.1371/journal.pone.0034221. Epub 2012 Mar 28.

The prevalence of specific infections in UK prostate cancer patients was investigated. Serum from 84 patients and 62 controls was tested for neutralisation of xenotropic murine leukaemia virus-related virus (XMRV) Envelope. No reactivity was found in the patient samples. In addition, a further 100 prostate DNA samples were tested for XMRV, BK virus, Trichomonas vaginalis and human papilloma viruses by nucleic acid detection techniques. Despite demonstrating DNA integrity and assay sensitivity, we failed to detect the presence of any of these agents in DNA samples, bar one sample that was weakly positive for HPV16. Therefore we conclude that these infections are absent in this typical cohort of men with prostate cancer.

研究了英国前列腺癌患者中特定感染的流行情况。检测了 84 名患者和 62 名对照者的血清，以检测对异嗜性鼠白血病病毒相关病毒（XMRV）包膜的中和作用。在患者样本中未发现反应性。此外，还通过核酸检测技术对另外 100 个前列腺 DNA 样本进行了 XMRV、BK 病毒、阴道毛滴虫和人乳头瘤病毒的检测。尽管证明了 DNA 的完整性和检测的灵敏度，但我们未能在 DNA 样本中检测到这些病原体的存在，除了一个 HPV16 弱阳性的样本。因此，我们得出结论，这些感染在这一典型的前列腺癌男性队列中不存在。