Lu Xiao-Feng, Yang Wei-Liang, Wan Zhen-Hai, Li Jia, Bi Zheng-Gang
The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Asian Pac J Cancer Prev. 2011;12(12):3357-60.
We aimed to study the potential role of GSTM1 and GSTT1 in the risk of osteosarcoma in Chinese population.
We collected 110 osteosarcomas by pathologic examination and 226 controls from the First Affiliated Hospital of Harbin Medical University during December 2008 to December 2010. Genotyping was based upon duplex polymerase-chain-reaction with the PCR-CTPP method.
Individuals carrying null GSTM1 and GSTT1 had 1.50 and 2.07 fold risks of osteosarcoma when compared with non-null genotypes, respectively. The increased risk associated with the GSTT1 polymorphism seemed more evident among males (Null GSTT1 genotype vs. non-null genotype, adjusted OR= 2.43, 95% CI: 1.29-3.30) than females (adjusted OR =1.66, 95% CI: 1.02-2.78). The increased risk was also more evident among individuals aged 15 years or less (adjusted OR for null GSTT1 genotype vs. non-null genotype = 2.24, 95% CI: 1.20-3.24) than those aged more than 15 years (adjusted OR = 1.82, 95% CI: 1.07-2.95).
Our study of the association between polymorphisms in GSTM1 and GSTTI and the risk of osteosarcoma in a Chinese population provided evidence that null GSTTI might be a useful marker of susceptibility to osteosarcoma development, especially for male sand young age individuals.
我们旨在研究谷胱甘肽S-转移酶M1（GSTM1）和谷胱甘肽S-转移酶T1（GSTT1）在中国人群骨肉瘤风险中的潜在作用。
我们于2008年12月至2010年12月期间，从哈尔滨医科大学附属第一医院收集了110例经病理检查确诊的骨肉瘤病例和226例对照。基因分型采用PCR-CTPP法进行双重聚合酶链反应。
与非缺失基因型相比，携带GSTM1和GSTT1缺失基因型的个体患骨肉瘤的风险分别为1.50倍和2.07倍。GSTT1基因多态性相关的风险增加在男性中（缺失GSTT1基因型与非缺失基因型相比，校正比值比=2.43，95%可信区间：1.29-3.30）似乎比女性中（校正比值比=1.66，95%可信区间：1.02-2.78）更明显。在15岁及以下的个体中（缺失GSTT1基因型与非缺失基因型相比的校正比值比=2.24，95%可信区间：1.20-3.24），这种风险增加也比15岁以上的个体中（校正比值比=1.82，95%可信区间：1.07-2.95）更明显。
我们对中国人群中GSTM1和GSTT1基因多态性与骨肉瘤风险之间关联的研究提供了证据，表明GSTT1缺失可能是骨肉瘤发生易感性的一个有用标志物，尤其是对男性和年轻个体而言。
