Department of Psychiatry, Virginia Commonwealth University, Richmond, 23219-0126, USA.
Genes Brain Behav. 2012 Jul;11(5):539-44. doi: 10.1111/j.1601-183X.2012.00789.x. Epub 2012 May 3.
Self-esteem and well-being are important for successful aging, and some evidence suggests that self-esteem and well-being are associated with hippocampal volume, cognition and stress responsivity. Whereas most of this evidence is based on studies on older adults, we investigated self-esteem, well-being and hippocampal volume in 474 male middle-aged twins. Self-esteem was significantly positively correlated with hippocampal volume (0.09, P = 0.03 for left hippocampus, 0.10, P = 0.04 for right). Correlations for well-being were not significant (Ps > 0.05). There were strong phenotypic correlations between self-esteem and well-being (0.72, P < 0.001) and between left and right hippocampal volume (0.72, P < 0.001). In multivariate genetic analyses, a two-factor additive genetic and unique environmental (AE) model with well-being and self-esteem on one factor and left and right hippocampal volumes on the other factor fits the data better than Cholesky, independent pathway or common pathway models. The correlation between the two genetic factors was 0.12 (P = 0.03); the correlation between the environmental factors was 0.09 (P > 0.05). Our results indicate that largely different genetic and environmental factors underlie self-esteem and well-being on one hand and hippocampal volume on the other.
自尊和幸福感对成功老龄化很重要，有证据表明自尊和幸福感与海马体体积、认知和应激反应有关。虽然大部分证据都基于对老年人的研究，但我们调查了 474 名中年男性双胞胎的自尊、幸福感和海马体体积。自尊与海马体体积呈显著正相关（左侧海马体为 0.09，P=0.03，右侧海马体为 0.10，P=0.04）。幸福感的相关性不显著（P>0.05）。自尊和幸福感之间存在很强的表型相关性（0.72，P<0.001），左侧和右侧海马体体积之间也存在很强的表型相关性（0.72，P<0.001）。在多变量遗传分析中，双因素加性遗传和独特环境（AE）模型，将幸福感和自尊放在一个因素上，将左侧和右侧海马体体积放在另一个因素上，比 Cholesky、独立途径或共同途径模型更适合数据。两个遗传因素之间的相关性为 0.12（P=0.03）；环境因素之间的相关性为 0.09（P>0.05）。我们的结果表明，在一方面，自尊和幸福感，以及另一方面，海马体体积，受到很大不同的遗传和环境因素的影响。
