Li Gang, Li Danqing
College of Mathematics, South China University of Technology, Guangzhou, Guangdong, China; Guangzhou E-Government Center, Guangzhou, China.
Cancer Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Hum Immunol. 2016 May;77(5):418-25. doi: 10.1016/j.humimm.2016.03.006. Epub 2016 Mar 19.
The purpose of this study was to explore whether interleukin-10 (IL-10) gene promoter polymorphisms and their haplotypes contribute to the incidence of non-Hodgkin lymphoma (NHL).
A meta-analysis was conducted on the associations of the IL-10-3575T/A, -1082 G/A, -819 C/T, -592C/A polymorphisms and the haplotypes with NHL.
A total of 23 studies involving 21,563 NHL patients and 23,837 controls were included in the meta-analysis. Pooled results indicated that IL-10-3575T/A was associated with an increased risk of NHL based on the dominant model (OR: 1.095, 95% CI: 1.020-1.178), similar results were found for -1082A/G in the heterozygous and recessive models (OR: 1.042, 95% CI: 1.012-1.074; and OR: 1.034, 95% CI: 1.011-1.057, respectively). In the ethnic subgroup analysis, -3575T/A had an increased risk of NHL in Caucasians based on the homozygous model (OR: 1.071, 95% CI: 1.001-1.146), and similar results were found for -1082A/G in the heterozygous and recessive models (OR: 1.041, 95% CI: 1.009-1.075; and OR: 1.031, 95% CI: 1.008-1.055, respectively). When stratified by subtypes, -3575T/A and -1082A/G polymorphisms were found significant association with an increased risk of B cell lymphoma, specifically diffuse large B-cell lymphoma (DLBCL). Moreover, -3575T/A was associated with an increased risk of follicular lymphoma (FL) in the homozygous and recessive models. Furthermore, we observed that significantly increased risk of NHL and DLBCL were associated with the A-G-C-C haplotype (IL-10-3575T/A, -1082A/G, -819C/T and -592C/A), and a decreased risk of DLBCL subtype was associated with the T-A-C-C haplotype.
IL-10-3575T/A and -1082A/G polymorphisms were associated with altered NHL susceptibility, especially for Caucasians and B cell lymphoma. IL-10 (-3575T/A, -1082A/G, -819C/T and -592C/A) haplotype were associated with NHL and DLBCL subtype.
本研究旨在探讨白细胞介素-10（IL-10）基因启动子多态性及其单倍型是否与非霍奇金淋巴瘤（NHL）的发病有关。
对IL-10 -3575T/A、-1082G/A、-819C/T、-592C/A多态性及其单倍型与NHL的相关性进行荟萃分析。
荟萃分析共纳入23项研究，涉及21563例NHL患者和23837例对照。合并结果显示，基于显性模型，IL-10 -3575T/A与NHL风险增加相关（OR：1.095，95%CI：1.020 - 1.178）；在杂合子和隐性模型中，-1082A/G也有类似结果（OR分别为：1.042，95%CI：1.012 - 1.074；以及OR：1.034，95%CI：1.011 - 1.057）。在种族亚组分析中，基于纯合子模型，-3575T/A在白种人中使NHL风险增加（OR：1.071，95%CI：1.001 - 1.146）；在杂合子和隐性模型中，-1082A/G也有类似结果（OR分别为：1.041，95%CI：1.009 - 1.075；以及OR：1.031，95%CI：1.008 - 1.055）。按亚型分层时，发现-3575T/A和-1082A/G多态性与B细胞淋巴瘤风险增加显著相关，特别是弥漫性大B细胞淋巴瘤（DLBCL）。此外，在纯合子和隐性模型中，-3575T/A与滤泡性淋巴瘤（FL）风险增加相关。此外，我们观察到A - G - C - C单倍型（IL-10 -3575T/A、-1082A/G、-819C/T和-592C/A）与NHL和DLBCL风险显著增加相关，而T - A - C - C单倍型与DLBCL亚型风险降低相关。
IL-10 -3575T/A和-1082A/G多态性与NHL易感性改变有关，尤其是对白种人和B细胞淋巴瘤。IL-10（-3575T/A、-1082A/G、-819C/T和-592C/A）单倍型与NHL和DLBCL亚型有关。
