Department of Microbiology, Immunology and Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, 50312, USA.
The Department of Respiratory Medicine, The 2nd People's Hospital of Hefei and Hefei Hospital Affiliated to Anhui Medical University, Hefei, China.
Med Oncol. 2021 Apr 9;38(5):56. doi: 10.1007/s12032-021-01504-y.
Non-Hodgkin's lymphoma is a relatively common cancer with malignant tendencies. Although there is no current cure for the disease, research has been successful in figuring out the mechanisms of how the disease progresses, however, there is still a lot of unknowns, and more research must be done to find the ultimate cause of the disease. Interleukins and various cytokines play unique roles in the development of cancer. This review article summarizes the pathophysiology between certain interleukins and non-Hodgkin's lymphoma. Although TNF-α is not an interleukin, the article examines TNF-α due to its high correspondence with cancer. The article also describes a promising immunotherapy for the disease, while looking at immunotherapies that have been successful in other types of cancer and disease.
非霍奇金淋巴瘤是一种相对常见的具有恶性倾向的癌症。虽然目前还没有治愈这种疾病的方法，但研究已经成功地揭示了疾病进展的机制，但仍有许多未知因素，需要进一步研究以找到疾病的根本原因。白细胞介素和各种细胞因子在癌症的发展中发挥着独特的作用。本文综述了某些白细胞介素与非霍奇金淋巴瘤之间的病理生理学关系。虽然 TNF-α 不是白细胞介素，但由于它与癌症有很高的对应关系，本文也对 TNF-α 进行了研究。本文还描述了一种有前途的非霍奇金淋巴瘤免疫疗法，同时探讨了在其他类型的癌症和疾病中成功应用的免疫疗法。
