Department for Cranio- and Maxillofacial Surgery, Heinrich-Heine-Universität, Moorenstr, 5, D-40225 Düsseldorf, Germany.
Head Face Med. 2012 Apr 3;8:11. doi: 10.1186/1746-160X-8-11.
Cystadenolymphomas (Warthin's tumors) are the second most frequent lesions of the parotid gland. Due to their benign clinical behavior, the low rates of recurrence and malignant transformation they were classified as tumor-like lesions. In addition, a polyclonal growth of the epithelial components of the tumor could be detected. Warthin's tumors occur bilateral in 7-10%, whereas a multifocal appearance is extremely rare. Even if the pathogenesis is still unclear a heterotopia of salivary tissue during embryogenesis is the most likely explanation for the origin of these tumors in the upper neck and periparotideal region. Here we present a rare case of bilateral, multifocal, extraglandular Warthin's tumors in lymph nodes of the upper neck and give a brief review of the literature. If a primary malignancy can be excluded by a careful staging procedure prior to the operation an isolated excision of the lesions of the neck is the adequate treatment.
囊性腺淋巴瘤（Warthin 瘤）是腮腺第二常见的病变。由于其良性的临床行为、较低的复发率和恶性转化率，它们被归类为肿瘤样病变。此外，还可以检测到肿瘤上皮成分的多克隆生长。Warthin 瘤在 7-10%的情况下为双侧发生，而多灶性表现极为罕见。尽管发病机制尚不清楚，但在胚胎发生过程中涎腺组织的异位是这些肿瘤在上颈部和腮腺周围区域起源的最可能解释。本文报道了一例罕见的双侧、多灶性、外分泌腺 Warthin 瘤病例，并对文献进行了简要回顾。如果在手术前通过仔细的分期程序排除了原发性恶性肿瘤，那么单独切除颈部病变就是适当的治疗方法。
