Department of Clinical Pharmacy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia.
Acta Pharm. 2012 Mar;62(1):115-22. doi: 10.2478/v10007-012-0005-2.
The effect of supplementation with a fixed combination of antioxidants (beta-carotene, selenium, vitamins C and E) on serum lipids was monitored in patients with newly detected Graves' disease. Measurements were made prior to the commencement of therapy and after 30 and 60 days. Patients were randomized into two groups. Test group comprised patients who received antioxidant supplementation in addition to methimazole, while patients treated with methimazole only were in the control group. The concentration of total and HDL-cholesterol increased significantly in test and control groups (p < 0.05) but these groups did not differ significantly. Concentration of LDL-cholesterol increased significantly in the test group only (p < 0.005) and was significantly different from the control group 60 days after the commencement of therapy (p < 0.005). Significant increase in the LDL-cholesterol concentration in the test group requires further investigations.
补充抗氧化剂（β-胡萝卜素、硒、维生素 C 和 E）固定混合剂对新诊断的格雷夫斯病患者的血清脂质的影响进行了监测。在开始治疗前和 30 天后和 60 天后进行了测量。患者被随机分为两组。实验组患者除接受甲巯咪唑外还接受抗氧化剂补充治疗，而仅接受甲巯咪唑治疗的患者为对照组。实验组和对照组的总胆固醇和高密度脂蛋白胆固醇浓度均显著升高（p < 0.05），但两组之间无显著差异。仅实验组的 LDL-胆固醇浓度显著升高（p < 0.005），并且在治疗开始后 60 天与对照组有显著差异（p < 0.005）。实验组 LDL-胆固醇浓度的显著升高需要进一步研究。
