Bacic-Vrca Vesna, Skreb Franjo, Cepelak Ivana, Mayer Ljiljana, Kusic Zvonko, Petres Blanka
Department of Clinical Pharmacy, School of Pharmacy and Biochemistry, University of Zagreb, Croatia.
Clin Chem Lab Med. 2005;43(4):383-8. doi: 10.1515/CCLM.2005.069.
The effects of supplementation with a fixed combination of antioxidants (vitamins C and E, beta-carotene and selenium) on superoxide dismutase activity, copper and zinc concentrations, and total antioxidant status were monitored in erythrocytes derived from a group of patients with Graves' disease treated with methimazole, with respect to the rate of achieving euthyroidism. Thyroid-stimulating hormone (TSH), thyroid hormones and the above-mentioned parameters were measured before therapy, and on days 30 and 60 after therapy initiation. The patients receiving antioxidant supplementation along with methimazole therapy (group A, n = 27) achieved euthyroidism at a faster rate than those treated with methimazole alone (group B, n = 28). The activity of superoxide dismutase decreased significantly in both patient groups during the treatment; however, there was no significant difference between the groups. There was no significant change in the erythrocyte concentration of copper, whereas the zinc concentration and total antioxidant status showed significant between-group differences. The study results clearly show that antioxidant supplementation in the treatment of Graves' disease is justified, while zinc and total antioxidant status in erythrocytes seem to be sensitive indicators of the efficacy of supplemental therapy.
在一组接受甲巯咪唑治疗的格雷夫斯病患者的红细胞中，监测补充固定组合抗氧化剂（维生素C和E、β-胡萝卜素和硒）对超氧化物歧化酶活性、铜和锌浓度以及总抗氧化状态的影响，观察甲状腺功能正常化的速率。在治疗前以及治疗开始后的第30天和第60天测量促甲状腺激素（TSH）、甲状腺激素和上述参数。接受抗氧化剂补充剂联合甲巯咪唑治疗的患者（A组，n = 27）比单独接受甲巯咪唑治疗的患者（B组，n = 28）甲状腺功能正常化的速率更快。治疗期间，两组患者的超氧化物歧化酶活性均显著降低；然而，两组之间没有显著差异。红细胞铜浓度没有显著变化，而锌浓度和总抗氧化状态在组间显示出显著差异。研究结果清楚地表明，在格雷夫斯病治疗中补充抗氧化剂是合理的，而红细胞中的锌和总抗氧化状态似乎是补充治疗疗效的敏感指标。
