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实施美国疫苗接种建议前,糖尿病患者的乙肝疫苗基础免疫接种率。

Baseline hepatitis B vaccination coverage among persons with diabetes before implementing a U.S. recommendation for vaccination.

机构信息

Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, & TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States.

出版信息

Vaccine. 2012 May 14;30(23):3376-82. doi: 10.1016/j.vaccine.2012.03.055. Epub 2012 Apr 1.

Abstract

BACKGROUND

Recent data suggest that adults with diabetes are at increased risk of incident hepatitis B infection and may suffer increased morbidity or mortality from chronic hepatitis B infection. In October 2011, the Advisory Committee on Immunization Practices (ACIP) recommended hepatitis B vaccination (HepB) for persons with diabetes aged 19-59 years and stated that persons with diabetes aged 60 years and older should be considered for vaccination.

OBJECTIVE

To determine HepB coverage among persons with diabetes aged ≥19 years prior to implementation of the new ACIP recommendation and to determine predictors for vaccination.

METHODS

We used the 2009 National Health Interview Survey to determine weighted proportions of self-reported HepB coverage (≥1 and ≥3 doses) among persons with diabetes aged ≥19 years. A multivariable logistic regression analysis was performed to determine factors independently associated with vaccination.

RESULTS

Overall, 19.5% (95% CI: 17.4-21.6%) and 16.6% (14.7-18.6%) of persons with diabetes, aged ≥19 years, reported receiving ≥1 and ≥3 doses of HepB, respectively, compared with 30.3% (29.4-31.3%) and 26.5% (25.5-27.4%) among persons without diabetes. While unadjusted HepB coverage was higher among persons without diabetes, diabetes status was not associated with ≥1 or ≥3 dose vaccination. Among persons with diabetes, being a healthcare provider (OR 4.2, 2.5-7.0), ever tested for HIV (OR 2.6, 1.8-3.6), high-risk behaviors (OR 1.8, 1.0-3.4, P-value=0.053) and having some college education (OR 1.7, 1.2-2.4) were all independently associated with vaccination.

CONCLUSION

HepB coverage among persons with diabetes is low. These data can be used to provide a baseline for measuring future progress toward vaccination of persons with diabetes.

摘要

背景

最近的数据表明,糖尿病患者患乙型肝炎感染的风险增加,并且可能因慢性乙型肝炎感染而遭受更高的发病率或死亡率。2011 年 10 月,免疫实践咨询委员会(ACIP)建议为 19-59 岁的糖尿病患者接种乙型肝炎疫苗(HepB),并表示应考虑为 60 岁及以上的糖尿病患者接种疫苗。

目的

确定新 ACIP 建议实施前≥19 岁的糖尿病患者的 HepB 覆盖率,并确定疫苗接种的预测因素。

方法

我们使用 2009 年全国健康访谈调查来确定≥19 岁的糖尿病患者自我报告的 HepB 覆盖率(≥1 剂和≥3 剂)的加权比例。进行多变量逻辑回归分析,以确定与接种疫苗独立相关的因素。

结果

总体而言,19.5%(95%CI:17.4-21.6%)和 16.6%(14.7-18.6%)的≥19 岁的糖尿病患者报告接受了≥1 剂和≥3 剂 HepB,而无糖尿病的患者中这一比例分别为 30.3%(29.4-31.3%)和 26.5%(25.5-27.4%)。虽然未调整的 HepB 覆盖率在无糖尿病的患者中较高,但糖尿病状态与≥1 剂或≥3 剂接种无关。在糖尿病患者中,作为医疗保健提供者(OR 4.2,2.5-7.0)、曾经接受过 HIV 检测(OR 2.6,1.8-3.6)、高危行为(OR 1.8,1.0-3.4,P 值=0.053)和接受过一些大学教育(OR 1.7,1.2-2.4)与接种疫苗均独立相关。

结论

糖尿病患者的 HepB 覆盖率较低。这些数据可用于提供衡量未来糖尿病患者疫苗接种进展的基线。

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